Matches in SemOpenAlex for { <https://semopenalex.org/work/W2502133115> ?p ?o ?g. }
- W2502133115 abstract "Abstract Recent studies have shown that crude oil exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling. We previously found that eggs of Atlantic haddock ( Melanogrammus aeglefinus ) bind dispersed oil droplets, potentially leading to more profound toxic effects from uptake of polycyclic aromatic hydrocarbons (PAHs). Using lower concentrations of dispersed crude oil (0.7–7 μg/L ∑PAH), here we exposed a broader range of developmental stages over both short and prolonged durations. We quantified effects on cardiac function and morphogenesis, characterized novel craniofacial defects, and examined the expression of genes encoding potential targets underlying cardiac and craniofacial defects. Because of oil droplet binding, a 24-hr exposure was sufficient to create severe cardiac and craniofacial abnormalities. The specific nature of the craniofacial abnormalities suggests that crude oil may target common craniofacial and cardiac precursor cells either directly or indirectly by affecting ion channels and intracellular calcium in particular. Furthermore, down-regulation of genes encoding specific components of the EC coupling machinery suggests that crude oil disrupts excitation-transcription coupling or normal feedback regulation of ion channels blocked by PAHs. These data support a unifying hypothesis whereby depletion of intracellular calcium pools by crude oil-derived PAHs disrupts several pathways critical for organogenesis in fish." @default.
- W2502133115 created "2016-08-23" @default.
- W2502133115 creator A5019054105 @default.
- W2502133115 creator A5019765244 @default.
- W2502133115 creator A5025470657 @default.
- W2502133115 creator A5052148605 @default.
- W2502133115 creator A5052188635 @default.
- W2502133115 creator A5060744496 @default.
- W2502133115 creator A5064897515 @default.
- W2502133115 creator A5066872698 @default.
- W2502133115 creator A5067631894 @default.
- W2502133115 creator A5069051315 @default.
- W2502133115 creator A5070266756 @default.
- W2502133115 creator A5075420061 @default.
- W2502133115 date "2016-08-10" @default.
- W2502133115 modified "2023-10-11" @default.
- W2502133115 title "Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development" @default.
- W2502133115 cites W1015033914 @default.
- W2502133115 cites W1546067468 @default.
- W2502133115 cites W1582383085 @default.
- W2502133115 cites W1962411499 @default.
- W2502133115 cites W1964958795 @default.
- W2502133115 cites W1965421782 @default.
- W2502133115 cites W1966594837 @default.
- W2502133115 cites W1970669147 @default.
- W2502133115 cites W1974712344 @default.
- W2502133115 cites W1983613007 @default.
- W2502133115 cites W1985716327 @default.
- W2502133115 cites W1986044147 @default.
- W2502133115 cites W1990131329 @default.
- W2502133115 cites W1992109292 @default.
- W2502133115 cites W1993528036 @default.
- W2502133115 cites W1994683039 @default.
- W2502133115 cites W1997602332 @default.
- W2502133115 cites W1997628145 @default.
- W2502133115 cites W1997777027 @default.
- W2502133115 cites W2013048291 @default.
- W2502133115 cites W2020920691 @default.
- W2502133115 cites W2022892895 @default.
- W2502133115 cites W2023109297 @default.
- W2502133115 cites W2023206260 @default.
- W2502133115 cites W2026663929 @default.
- W2502133115 cites W2029402099 @default.
- W2502133115 cites W2029888767 @default.
- W2502133115 cites W2030310703 @default.
- W2502133115 cites W2031609963 @default.
- W2502133115 cites W2033984390 @default.
- W2502133115 cites W2035985796 @default.
- W2502133115 cites W2036063545 @default.
- W2502133115 cites W2037705608 @default.
- W2502133115 cites W2038510857 @default.
- W2502133115 cites W2048805957 @default.
- W2502133115 cites W2050824263 @default.
- W2502133115 cites W2051031547 @default.
- W2502133115 cites W2054437143 @default.
- W2502133115 cites W2057718103 @default.
- W2502133115 cites W2058037026 @default.
- W2502133115 cites W2058207889 @default.
- W2502133115 cites W2061702716 @default.
- W2502133115 cites W2065396393 @default.
- W2502133115 cites W2071573213 @default.
- W2502133115 cites W2077179726 @default.
- W2502133115 cites W2081885557 @default.
- W2502133115 cites W2082235062 @default.
- W2502133115 cites W2086843187 @default.
- W2502133115 cites W2089238497 @default.
- W2502133115 cites W2091357612 @default.
- W2502133115 cites W2098434620 @default.
- W2502133115 cites W2108415927 @default.
- W2502133115 cites W2112392627 @default.
- W2502133115 cites W2112591804 @default.
- W2502133115 cites W2113130311 @default.
- W2502133115 cites W2113416822 @default.
- W2502133115 cites W2118571697 @default.
- W2502133115 cites W2120235933 @default.
- W2502133115 cites W2121155069 @default.
- W2502133115 cites W2125411585 @default.
- W2502133115 cites W2125491749 @default.
- W2502133115 cites W2132274358 @default.
- W2502133115 cites W2133513686 @default.
- W2502133115 cites W2139760360 @default.
- W2502133115 cites W2143712822 @default.
- W2502133115 cites W2150627711 @default.
- W2502133115 cites W2152513067 @default.
- W2502133115 cites W2156424039 @default.
- W2502133115 cites W2164308224 @default.
- W2502133115 cites W2172278621 @default.
- W2502133115 cites W2190928574 @default.
- W2502133115 cites W2277299046 @default.
- W2502133115 cites W2315459591 @default.
- W2502133115 cites W2318369817 @default.
- W2502133115 cites W2346697168 @default.
- W2502133115 cites W2397281151 @default.
- W2502133115 cites W2440035807 @default.
- W2502133115 cites W2791260982 @default.
- W2502133115 cites W32004560 @default.
- W2502133115 cites W652451007 @default.
- W2502133115 doi "https://doi.org/10.1038/srep31058" @default.
- W2502133115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4979050" @default.
- W2502133115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27506155" @default.