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• W2502445994 endingPage "74" @default.
• W2502445994 startingPage "43" @default.
• W2502445994 abstract "Pathogenic bacteria synthesize a diverse array of virulence determinants. These virulence proteins, which comprise the arsenal of bacterial weapons, have a wide variety of activities that require them to be targeted to specific locations. For instance, proteins involved in attachment of the bacterium to the host cell must be localized to the bacterial surface, some bacterial toxins are secreted into surrounding fluids, and others are injected directly into the cytoplasm of the eukaryotic host cell. Thus, in pathogenic bacteria secretion itself is a virulence determinant; without the means to selectively target proteins, these bacteria are harmless. The problem of targeting proteins to their correct location is not unique to pathogenic bacteria. All cells have subcellular compartments that are bound by lipid bilayers, and it is essential that each of these compartments contain a characteristic set of proteins. To maintain this organization, cells have specific mechanisms to target proteins from their site of synthesis in the cytoplasm to each noncytoplasmic location." @default.
• W2502445994 created "2016-08-23" @default.
• W2502445994 creator A5004277246 @default.
• W2502445994 creator A5078299650 @default.
• W2502445994 date "2001-01-01" @default.
• W2502445994 modified "2023-09-25" @default.
• W2502445994 title "Germ Warfare: The Mechanisms of Virulence Factor Delivery" @default.
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