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- W2502446707 abstract "Publisher Summary This chapter reviews some of the recent developments of whole-cell and isolated enzymes in chiral synthesis. Hydrolases are predominant biocatalysts used for chiral synthesis due to its wide availability, ease of use, and high compatibility with organic solvents. Tremendous progress has been made in recent years in using biocatalysis for chiral synthesis. Heterologous expression, directed evolution, and metabolic engineering have become indispensable tools in developing enzyme and whole-cell catalysts. Great strides have been made in solving several long-standing problems, such as cofactor regeneration. An important whole-cell biocatalysis issue, the slower reaction rate rooted in the limited substrate permeability in whole-cell biocatalysis, is being addressed using molecular engineering approaches. The challenges ahead are to shorten the time required for biocatalyst development and process development to the level comparable to a typical chemical catalysis process. It is expected that the increasing use of high-throughput technology, embracing various bioinformatics tools made available only recently, and advances in the understanding of enzymatic catalysis mechanisms, protein structure and function relationships, and the fundamentals of metabolic pathways and regulation bring about more widespread use of biocatalysts in chiral synthesis." @default.
- W2502446707 created "2016-08-23" @default.
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- W2502446707 date "2007-01-01" @default.
- W2502446707 modified "2023-09-27" @default.
- W2502446707 title "Biocatalysis for Chiral Synthesis" @default.
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- W2502446707 doi "https://doi.org/10.1016/b978-044452114-9/50014-1" @default.
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