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- W2502869909 abstract "INTERACTIONS BETWEEN MURINE PERITONEAL MACROPHAGES AND NAEGLERIA FOWLER! Leigh A. Belcher, M.S. Medical College of Virginia Virginia Commonwealth University, 1983. Major Director: Dr. Francine Marciano-Cabral In the present study, we have examined the differences among Corynebacterium parvum-activated, thioglycollateelicited, and resident macrophages from (CS?BL/6 X C3H)F1 mice utilizing two microcytotoxicity assays. Macrophage and Naegleria fowleri were interchangeably employed as effector and target cells. To assess the ability of the macrophage to lyse �fowleri, the amoebae were labeled with 5 μCi of 3H-uridine per 5 x 10 5 cells for 18 h prior to co-culturing with adherent macrophage monolayers. Although the macrophage-induced lysis was density and time dependent, f. parvum macrophages consistently demonstrated an increased cytotoxic response to�fowleri after 24 h co-incubation at a 10:1 effector-to-target ratio. In contrast, thioglycollate and resident macrophages were unable to elicit a cytotoxic response to N. fowleri." @default.
- W2502869909 created "2016-08-23" @default.
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- W2502869909 date "1983-01-01" @default.
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- W2502869909 title "Interactions Between Murine Peritoneal Macrophages and Naegleria Fowleri" @default.
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- W2502869909 doi "https://doi.org/10.25772/bewj-8747" @default.
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