FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2502894563> ?p ?o ?g. }

• W2502894563 abstract "Cortex Phellodendri (C. Phellodendri), the dried trunk bark of Phellodendron amurense Ruprecht, has been known as a traditional herbal medicine, showing several bioactivities. However, antiviral activity of C. Phellodendri aqueous extract (CP) not reported in detail, particularly aiming the prophylactic effectiveness. In vitro CP antiviral activity evaluated against Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Newcastle Disease Virus (NDV), Herpes Simplex Virus (HSV), Coxsackie Virus (H3-GFP) and Enterovirus-71 (EV-71) infection on immune (RAW264.7) and epithelial (HEK293T/HeLa) cells. Such antiviral effects were explained by the induction of antiviral state which was determined by phosphorylation of signal molecules, secretion of IFNs and cytokines, and cellular antiviral mRNA expression. Furthermore, Compounds present in the aqueous fractions confirmed by HPLC analysis and evaluated their anti-viral activities. Additionally, in vivo protective effect of CP against divergent influenza A subtypes was determined in a BALB/c mouse infection model. An effective dose of CP significantly reduced the virus replication both in immune and epithelial cells. Mechanically, CP induced mRNA expression of anti-viral genes and cytokine secretion in both RAW264.7 and HEK293T cells. Furthermore, the main compound identified was berberine, and shows promising antiviral properties similar to CP. Finally, BALB/c mice treated with CP displayed higher protection levels against lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3 and H9N2). CP including berberine play an immunomodulatory role with broad spectrum antiviral activity, due to induction of antiviral state via type I IFN stimulation mechanism. Consequently, C. Phellodendri could be a potential source for promising natural antivirals or to design other antiviral agents for animal and humans." @default.
• W2502894563 created "2016-08-23" @default.
• W2502894563 creator A5000251053 @default.
• W2502894563 creator A5009491284 @default.
• W2502894563 creator A5014898125 @default.
• W2502894563 creator A5019083787 @default.
• W2502894563 creator A5024610841 @default.
• W2502894563 creator A5026216541 @default.
• W2502894563 creator A5033219937 @default.
• W2502894563 creator A5040824493 @default.
• W2502894563 creator A5060221019 @default.
• W2502894563 creator A5077269914 @default.
• W2502894563 creator A5079822167 @default.
• W2502894563 creator A5085298796 @default.
• W2502894563 date "2016-08-02" @default.
• W2502894563 modified "2023-10-18" @default.
• W2502894563 title "Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo" @default.
• W2502894563 cites W1967686012 @default.
• W2502894563 cites W1984834259 @default.
• W2502894563 cites W1985118687 @default.
• W2502894563 cites W1994095345 @default.
• W2502894563 cites W2002729899 @default.
• W2502894563 cites W2026543323 @default.
• W2502894563 cites W2029607802 @default.
• W2502894563 cites W2031973851 @default.
• W2502894563 cites W2038002801 @default.
• W2502894563 cites W2042475024 @default.
• W2502894563 cites W2043504114 @default.
• W2502894563 cites W2054895983 @default.
• W2502894563 cites W2059938714 @default.
• W2502894563 cites W2073875274 @default.
• W2502894563 cites W2076251351 @default.
• W2502894563 cites W2086040094 @default.
• W2502894563 cites W2089077517 @default.
• W2502894563 cites W2089461532 @default.
• W2502894563 cites W2097980864 @default.
• W2502894563 cites W2110378444 @default.
• W2502894563 cites W2122144437 @default.
• W2502894563 cites W2128513949 @default.
• W2502894563 cites W2130172183 @default.
• W2502894563 cites W2130810477 @default.
• W2502894563 cites W2139233177 @default.
• W2502894563 cites W2143214524 @default.
• W2502894563 cites W2170319845 @default.
• W2502894563 cites W2171918265 @default.
• W2502894563 cites W4230982340 @default.
• W2502894563 cites W44460526 @default.
• W2502894563 doi "https://doi.org/10.1186/s12906-016-1206-x" @default.
• W2502894563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4970287" @default.
• W2502894563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27484768" @default.
• W2502894563 hasPublicationYear "2016" @default.
• W2502894563 type Work @default.
• W2502894563 sameAs 2502894563 @default.
• W2502894563 citedByCount "22" @default.
• W2502894563 countsByYear W25028945632016 @default.
• W2502894563 countsByYear W25028945632017 @default.
• W2502894563 countsByYear W25028945632018 @default.
• W2502894563 countsByYear W25028945632019 @default.
• W2502894563 countsByYear W25028945632020 @default.
• W2502894563 countsByYear W25028945632021 @default.
• W2502894563 countsByYear W25028945632022 @default.
• W2502894563 countsByYear W25028945632023 @default.
• W2502894563 crossrefType "journal-article" @default.
• W2502894563 hasAuthorship W2502894563A5000251053 @default.
• W2502894563 hasAuthorship W2502894563A5009491284 @default.
• W2502894563 hasAuthorship W2502894563A5014898125 @default.
• W2502894563 hasAuthorship W2502894563A5019083787 @default.
• W2502894563 hasAuthorship W2502894563A5024610841 @default.
• W2502894563 hasAuthorship W2502894563A5026216541 @default.
• W2502894563 hasAuthorship W2502894563A5033219937 @default.
• W2502894563 hasAuthorship W2502894563A5040824493 @default.
• W2502894563 hasAuthorship W2502894563A5060221019 @default.
• W2502894563 hasAuthorship W2502894563A5077269914 @default.
• W2502894563 hasAuthorship W2502894563A5079822167 @default.
• W2502894563 hasAuthorship W2502894563A5085298796 @default.
• W2502894563 hasBestOaLocation W25028945631 @default.
• W2502894563 hasConcept C140704245 @default.
• W2502894563 hasConcept C150903083 @default.
• W2502894563 hasConcept C159047783 @default.
• W2502894563 hasConcept C202751555 @default.
• W2502894563 hasConcept C203014093 @default.
• W2502894563 hasConcept C207001950 @default.
• W2502894563 hasConcept C2522874641 @default.
• W2502894563 hasConcept C2775996393 @default.
• W2502894563 hasConcept C2777366897 @default.
• W2502894563 hasConcept C2777546802 @default.
• W2502894563 hasConcept C2780116568 @default.
• W2502894563 hasConcept C2781196997 @default.
• W2502894563 hasConcept C55493867 @default.
• W2502894563 hasConcept C86803240 @default.
• W2502894563 hasConcept C8891405 @default.
• W2502894563 hasConcept C98274493 @default.
• W2502894563 hasConceptScore W2502894563C140704245 @default.
• W2502894563 hasConceptScore W2502894563C150903083 @default.
• W2502894563 hasConceptScore W2502894563C159047783 @default.
• W2502894563 hasConceptScore W2502894563C202751555 @default.
• W2502894563 hasConceptScore W2502894563C203014093 @default.
• W2502894563 hasConceptScore W2502894563C207001950 @default.
• W2502894563 hasConceptScore W2502894563C2522874641 @default.
• W2502894563 hasConceptScore W2502894563C2775996393 @default.

• next