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- W2503035002 endingPage "R422" @default.
- W2503035002 startingPage "R411" @default.
- W2503035002 abstract "Ovarian cancer has the highest mortality of all female reproductive cancers. Late diagnosis, tumour heterogeneity and the development of chemoresistance contribute to this statistic and work against patient survival. Current studies have revealed novel concepts that impact our view on how ovarian cancer develops. The greatest impact is on our understanding that, as a disease, ovarian cancer has multiple cellular origins and that these malignant precursors are mostly derived from outside of the ovaries. In this review, we propose a new concept of a step-wise developmental process that may underwrite ovarian tumorigenesis and progression: (1) migration/recruitment to the ovaries; (2) seeding and establishment in the ovaries; (3) induction of a dormant cancer stage; and (4) expansion and tumor progression. We will discuss the relationship of each step with the changing ovarian function and milieu during the reproductive age and the subsequent occurrence of menopause. The realization that ovarian cancer development and progression occurs in distinct steps is critical for the search of adequate markers for early detection that will offer personalized strategies for prevention and therapy." @default.
- W2503035002 created "2016-08-23" @default.
- W2503035002 creator A5031020692 @default.
- W2503035002 creator A5075914683 @default.
- W2503035002 creator A5078106091 @default.
- W2503035002 creator A5088903979 @default.
- W2503035002 date "2016-09-01" @default.
- W2503035002 modified "2023-10-13" @default.
- W2503035002 title "Redefining the origin and evolution of ovarian cancer: a hormonal connection" @default.
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