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• W2503309612 abstract "This chapter describes the topic of gene therapy based on colloidal drug delivery, as an alternative to the use of viral carriers. Non-viral vectors are promising transfection agents and do not suffer from limitations related to toxicity and immunogenic effects. In particular, lipid-based aggregates are generally considered biocompatible and versatile nanocarriers whose composition can be designed to include a cationic molecule which ensures strong interaction with nucleic acid. Herein the main issues related to complex formation and in vitro administration are illustrated with key examples, such as liposome-DNA plasmid (pDNA) association and micelles-siRNA complexes." @default.
• W2503309612 created "2016-08-23" @default.
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• W2503309612 date "2016-01-01" @default.
• W2503309612 modified "2023-09-27" @default.
• W2503309612 title "Lipoplexes from Non-viral Cationic Vectors: DOTAP-DOPE Liposomes and Gemini Micelles" @default.
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• W2503309612 doi "https://doi.org/10.1007/978-1-4939-3718-9_3" @default.
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