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- W2503420725 abstract "COPD definition requires post-bronchodilator (BD) spirometry. In epidemiological studies where post-BD spirometry was not performed, COPD is generally defined using pre-BD spirometry. However, the extent of misclassification in this definition is unknown. Using the data of 3,332 subjects who underwent spirometry both in the European Community Respiratory Health Survey II (pre-BD) (1999/2001) and III (pre + post-BD) (2010/2014), we assessed the validity of a definition of pre-BD “chronic” (present at both ECRHS II and III) airflow obstruction, towards post-BD (“fixed”) obstruction at ECRHS III (the gold standard). Airflow obstruction was defined as FEV1/FVC Subjects were 54.1±7.1 year-old at baseline, 53% were women. Chronic and fixed obstruction were present in 163 (4.9%) and 188 (5.6%) individuals, respectively. Subjects who had obstruction according to both definitions (n=136) were more likely to be smokers (73 vs 54%) and to have asthma (62 vs 19%) than subjects without chronic/fixed obstruction (n=3,117) (both p 0.05). In young adults, pre-BD airflow obstruction confirmed at two occasions 9 years apart correctly identified the large majority of subjects with post-BD airflow obstruction." @default.
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- W2503420725 date "2015-09-01" @default.
- W2503420725 modified "2023-10-07" @default.
- W2503420725 title "Can we use pre-bronchodilator spirometry to define post-bronchodilator airflow obstruction?" @default.
- W2503420725 doi "https://doi.org/10.1183/13993003.congress-2015.pa5065" @default.
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