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- W2503492805 endingPage "126" @default.
- W2503492805 startingPage "113" @default.
- W2503492805 abstract "Misfolded tau proteins are characteristic of tauopathies, but the isoform composition of tau inclusions varies by tauopathy. Using aggregates of the longest tau isoform (containing 4 microtubule-binding repeats and 4-repeat tau), we recently described a direct mechanism of toxicity that involves exposure of the N-terminal phosphatase-activating domain (PAD) in tau, which triggers a signaling pathway that disrupts axonal transport. However, the impact of aggregation on PAD exposure for other tau isoforms was unexplored. Here, results from immunochemical assays indicate that aggregation-induced increases in PAD exposure and oligomerization are common features among all tau isoforms. The extent of PAD exposure and oligomerization was larger for tau aggregates composed of 4-repeat isoforms compared with those made of 3-repeat isoforms. Most important, aggregates of all isoforms exhibited enough PAD exposure to significantly impair axonal transport in the squid axoplasm. We also show that PAD exposure and oligomerization represent common pathological characteristics in multiple tauopathies. Collectively, these results suggest a mechanism of toxicity common to each tau isoform that likely contributes to degeneration in different tauopathies." @default.
- W2503492805 created "2016-08-23" @default.
- W2503492805 creator A5017207366 @default.
- W2503492805 creator A5028157111 @default.
- W2503492805 creator A5028912017 @default.
- W2503492805 creator A5058133079 @default.
- W2503492805 creator A5058343292 @default.
- W2503492805 creator A5070073548 @default.
- W2503492805 date "2016-11-01" @default.
- W2503492805 modified "2023-10-17" @default.
- W2503492805 title "Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition" @default.
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