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- W2503511058 abstract "Abstract Myeloid-derived suppressor cells (MDSCs) are highly prevalent inflammatory cells that play a key role in tumor development and are considered therapeutic targets. MDSCs promote tumor growth by blocking T-cell-mediated anti-tumoral immune response through depletion of arginine that is essential for T-cell proliferation. To deplete arginine, MDSCs express high levels of arginase, which catalyzes the breakdown of arginine into urea and ornithine. Here, we developed a new hyperpolarized 13 C probe, [6- 13 C]-arginine, to image arginase activity. We show that [6- 13 C]-arginine can be hyperpolarized and hyperpolarized [ 13 C]-urea production from [6- 13 C]-arginine is linearly correlated with arginase concentration in vitro . Furthermore we show that we can detect a statistically significant increase in hyperpolarized [ 13 C]-urea production in MDSCs when compared to control bone marrow cells. This increase was associated with an increase in intracellular arginase concentration detected using a spectrophotometric assay. Hyperpolarized [6- 13 C]-arginine could therefore serve to image tumoral MDSC function and more broadly M2-like macrophages." @default.
- W2503511058 created "2016-08-23" @default.
- W2503511058 creator A5003583564 @default.
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- W2503511058 creator A5088787388 @default.
- W2503511058 date "2016-08-10" @default.
- W2503511058 modified "2023-09-25" @default.
- W2503511058 title "Detection of inflammatory cell function using 13C magnetic resonance spectroscopy of hyperpolarized [6-13C]-arginine" @default.
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- W2503511058 doi "https://doi.org/10.1038/srep31397" @default.
- W2503511058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4979036" @default.
- W2503511058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27507680" @default.
- W2503511058 hasPublicationYear "2016" @default.
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