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• W2503669109 endingPage "427" @default.
• W2503669109 startingPage "405" @default.
• W2503669109 abstract "This chapter summarizes the current understanding of cell cycle regulation in cardiac myocytes and the molecular connections among proliferation, differentiation, and apoptosis in the developing heart. Clinical syndromes in which these events are germane include, most obviously, hypoplastic heart syndromes and many common congenital heart defects but also the less familiar disorder, noncompaction. Moreover, it has been suggested, in other contexts, that hypertrophic growth may be a forme fruste of cell-cycle reentry, with the imposition of a block at the G1/S checkpoint through pocket protein action; direct tests are needed, however, to assess the possible relevance of this model to agonist- and load-induced myocardial hypertrophy. A link between cell cycle regulators and death signals that might not be considered in the context of cycling is shown by the degradation of Rb via an ICE-like protease during apoptosis as well as by the ability of a cleavage-resistant Rb to protect cells from certain apoptotic triggers. Beyond this role in pathophysiology, apoptosis is also believed to contribute to normal cardiac morphogenesis, such as during the normal regression of the right ventricle upon unloading after birth. It remains unknown whether differential rates of proliferation, apoptosis, or alternative events explain the mechanics of how looping morphogenesis proceeds." @default.
• W2503669109 created "2016-08-23" @default.
• W2503669109 creator A5030966202 @default.
• W2503669109 creator A5051287989 @default.
• W2503669109 date "1999-01-01" @default.
• W2503669109 modified "2023-10-11" @default.
• W2503669109 title "The Cardiac Cell Cycle" @default.
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