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- W2503749811 startingPage "35" @default.
- W2503749811 abstract "Acyl glucuronides can be reactive metabolites capable of undergoing hydrolysis, intramolecular acyl migration, and covalent binding to proteins, both in vitro and in vivo. Glucuronidation occurs primarily in the liver and intestines, and is the major route of elimination for many xenobiotic and endogenous compounds containing a carboxylic acid function. Although glucuronidation is recognized as a detoxification process, acyl-linked glucuronides are considered chemically reactive electrophiles capable of covalent modification with nucleophilic sites on proteins. The extent of covalent binding with lysine amino groups of proteins correlates well with acyl glucuronide degradation rates (acyl migration and hydrolysis) and occurs either through a direct transacylation reaction or by a Schiff base mechanism via the open-chain aldehyde form of the acyl-migrated isomer. Subsequent formation of drug protein adducts has been proposed to elicit a direct toxicity or an immune-based reaction, both of which are consistent with the idiosyncratic toxicity commonly associated with carboxylic acid-containing drugs." @default.
- W2503749811 created "2016-08-23" @default.
- W2503749811 creator A5030120637 @default.
- W2503749811 creator A5058859139 @default.
- W2503749811 creator A5075960682 @default.
- W2503749811 date "2013-01-01" @default.
- W2503749811 modified "2023-10-03" @default.
- W2503749811 title "Mechanistic Role of Acyl Glucuronides" @default.
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