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• W2503870809 endingPage "369" @default.
• W2503870809 startingPage "357" @default.
• W2503870809 abstract "Recent genome-wide association studies have linked a number of Wnt signaling pathway components, including certain Wnt ligand, the Wnt coreceptor LRP5, and the Wnt pathway effector TCF7L2, with the risk of type 2 diabetes and other metabolic disorders, whereas intensive cell and molecular biology bench work have shown the great contribution of Wnt signaling pathway in metabolic homeostasis in health and diseases. In this review, the basic knowledge of the canonical Wnt signaling pathway and the involvement of Wnt pathway components in diabetes and metabolic homeostasis is introduced. Then, current findings are presented as well as a dispute on the role of the Wnt signaling pathway effector TCF7L2 in controlling glucose homeostasis. This is followed by the view that the Wnt signaling pathway effector β-catenin/TCF mediates the function of metabolic hormones in response to nutritional challenge in health and diseases." @default.
• W2503870809 created "2016-08-23" @default.
• W2503870809 creator A5039579465 @default.
• W2503870809 date "2016-01-01" @default.
• W2503870809 modified "2023-09-26" @default.
• W2503870809 title "Current Knowledge on the Role of Wnt Signaling Pathway in Glucose Homeostasis" @default.
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