Matches in SemOpenAlex for { <https://semopenalex.org/work/W2504017776> ?p ?o ?g. }
- W2504017776 endingPage "7597" @default.
- W2504017776 startingPage "7584" @default.
- W2504017776 abstract "Recent efforts have been focused on the development of centrally active COMT inhibitors, which can be valuable assets for neurological disorders such as Parkinson’s disease, due to the severe hepatotoxicity risk associated with tolcapone. New nitrocatechol COMT inhibitors based on naturally occurring caffeic acid and caffeic acid phenethyl ester were developed. All nitrocatechol derivatives displayed potent inhibition of peripheral and cerebral COMT within the nanomolar range. Druglike derivatives 13, 15, and 16 were predicted to cross the blood–brain barrier in vitro and were significantly less toxic than tolcapone and entacapone when incubated at 50 μM with rat primary hepatocytes. Moreover, their unique acidity and electrochemical properties decreased the chances of formation of reactive quinone-imines and, as such, the potential for hepatotoxicity. The binding mode of 16 confirmed that the major interactions with COMT were established via the nitrocatechol ring, allowing derivatization of the side chain for future lead optimization efforts." @default.
- W2504017776 created "2016-08-23" @default.
- W2504017776 creator A5004636866 @default.
- W2504017776 creator A5015932612 @default.
- W2504017776 creator A5022078029 @default.
- W2504017776 creator A5028669057 @default.
- W2504017776 creator A5031031415 @default.
- W2504017776 creator A5051486403 @default.
- W2504017776 creator A5058065577 @default.
- W2504017776 creator A5064181719 @default.
- W2504017776 creator A5068000809 @default.
- W2504017776 creator A5070602119 @default.
- W2504017776 creator A5077833960 @default.
- W2504017776 creator A5078712323 @default.
- W2504017776 creator A5080257551 @default.
- W2504017776 creator A5084466438 @default.
- W2504017776 date "2016-08-05" @default.
- W2504017776 modified "2023-10-17" @default.
- W2504017776 title "Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol <i>O</i>-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity" @default.
- W2504017776 cites W1503791974 @default.
- W2504017776 cites W1518956512 @default.
- W2504017776 cites W1543624067 @default.
- W2504017776 cites W1600621704 @default.
- W2504017776 cites W1648368538 @default.
- W2504017776 cites W1963824779 @default.
- W2504017776 cites W1964066906 @default.
- W2504017776 cites W1970128454 @default.
- W2504017776 cites W1972057863 @default.
- W2504017776 cites W1972638000 @default.
- W2504017776 cites W1973485004 @default.
- W2504017776 cites W1975341845 @default.
- W2504017776 cites W1977138162 @default.
- W2504017776 cites W1978009405 @default.
- W2504017776 cites W1978115406 @default.
- W2504017776 cites W1982616266 @default.
- W2504017776 cites W1982711363 @default.
- W2504017776 cites W1988474051 @default.
- W2504017776 cites W1988485031 @default.
- W2504017776 cites W1989842308 @default.
- W2504017776 cites W1993826844 @default.
- W2504017776 cites W1996395058 @default.
- W2504017776 cites W1998026876 @default.
- W2504017776 cites W2000056831 @default.
- W2504017776 cites W2003612344 @default.
- W2504017776 cites W2008288225 @default.
- W2504017776 cites W2008525757 @default.
- W2504017776 cites W2009979602 @default.
- W2504017776 cites W2010418141 @default.
- W2504017776 cites W2016575780 @default.
- W2504017776 cites W2025642899 @default.
- W2504017776 cites W2026976753 @default.
- W2504017776 cites W2033881399 @default.
- W2504017776 cites W2045949372 @default.
- W2504017776 cites W2059952048 @default.
- W2504017776 cites W2062458432 @default.
- W2504017776 cites W2065457701 @default.
- W2504017776 cites W2069723443 @default.
- W2504017776 cites W2071578856 @default.
- W2504017776 cites W2071887337 @default.
- W2504017776 cites W2072531628 @default.
- W2504017776 cites W2077878281 @default.
- W2504017776 cites W2091691135 @default.
- W2504017776 cites W2094648998 @default.
- W2504017776 cites W2095431796 @default.
- W2504017776 cites W2096712882 @default.
- W2504017776 cites W2100690704 @default.
- W2504017776 cites W2108405162 @default.
- W2504017776 cites W2112120783 @default.
- W2504017776 cites W2114032240 @default.
- W2504017776 cites W2117154880 @default.
- W2504017776 cites W2117744958 @default.
- W2504017776 cites W2122137453 @default.
- W2504017776 cites W2135557869 @default.
- W2504017776 cites W2135732933 @default.
- W2504017776 cites W2152561013 @default.
- W2504017776 cites W2158625734 @default.
- W2504017776 cites W2315872757 @default.
- W2504017776 cites W2315881922 @default.
- W2504017776 cites W2318525664 @default.
- W2504017776 cites W2411729407 @default.
- W2504017776 cites W294304874 @default.
- W2504017776 cites W4376848489 @default.
- W2504017776 cites W67659642 @default.
- W2504017776 doi "https://doi.org/10.1021/acs.jmedchem.6b00666" @default.
- W2504017776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27463695" @default.
- W2504017776 hasPublicationYear "2016" @default.
- W2504017776 type Work @default.
- W2504017776 sameAs 2504017776 @default.
- W2504017776 citedByCount "30" @default.
- W2504017776 countsByYear W25040177762017 @default.
- W2504017776 countsByYear W25040177762018 @default.
- W2504017776 countsByYear W25040177762019 @default.
- W2504017776 countsByYear W25040177762020 @default.
- W2504017776 countsByYear W25040177762021 @default.
- W2504017776 countsByYear W25040177762022 @default.
- W2504017776 countsByYear W25040177762023 @default.
- W2504017776 crossrefType "journal-article" @default.
- W2504017776 hasAuthorship W2504017776A5004636866 @default.