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- W2504052342 abstract "Current understandings on the stereoselective metabolism and activation pathways of the weak carcinogen benz[a]anthracene and two of the potent carcinogens, benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, are reviewed. Different stereoselective pathways of metabolism occur in the formations of the procarcinogenic dihydrodiols, the bay-region dihydrodiol-epoxides, and the K-region dihydrodiols by rat liver microsomal enzymes. Recent evidence suggests that a methyl substituent at the C-12 position of benz[a]-anthracene enhances the carcinogenicity of the methylated hydrocarbon and also changes the stereoselective metabolism in the formation and hydration of the K-region 5,6-epoxide as well as the procarcinogenic 3,4-epoxide." @default.
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- W2504052342 date "1985-07-19" @default.
- W2504052342 modified "2023-10-16" @default.
- W2504052342 title "Stereoselective Metabolism and Activations of Polycyclic Aromatic Hydrocarbons" @default.
- W2504052342 doi "https://doi.org/10.1021/bk-1985-0283.ch002" @default.
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