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• W2504254042 endingPage "404" @default.
• W2504254042 startingPage "391" @default.
• W2504254042 abstract "For many years there has been much interest in identifying the spatial relationship between the organization of calcium channels and the sites for the release of chemical neurotransmitter (for a recent review, see ref. ). During this time, the debate has been fostered by biophysical studies concerning the relation between calcium and transmitter release. Many studies, for example, have asked whether multiple calcium ions are required for the release of neurotransmitter. With the frequent observation of an apparent cooperative relation between calcium influx and stimulated release, and the demonstration of very short latencies between calcium influx and the onset of the evoked synaptic potential/current, there has been much debate about the organization of calcium channels with respect to the secretory apparatus. Questions that frequently surface are how many channels surround a vesicle, is calcium influx through multiple calcium channels necessary for the release of neurotransmitter, and how closely do calcium channels cluster at a release site? Although these questions frequently surface, there have been few successful attempts to define the spatial organization of calcium channels in nerve terminals. This paucity of information is not owing to a lack of effort, but rather because of technical challenges that are associated with working within the limited space of a nerve terminal." @default.
• W2504254042 created "2016-08-23" @default.
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• W2504254042 date "2003-11-15" @default.
• W2504254042 modified "2023-09-23" @default.
• W2504254042 title "Imaging the Spatial Organization of Calcium Channels in Nerve Terminals Using Atomic Force Microscopy" @default.
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• W2504254042 doi "https://doi.org/10.1385/1-59259-118-3:391" @default.
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