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- W2504268164 endingPage "16.2016" @default.
- W2504268164 startingPage "ENEURO.0056" @default.
- W2504268164 abstract "Abstract The recruitment of additional neurons to neural circuits often occurs in accordance with changing functional demands. Here we found that synaptic recruitment plays a key role in functional recovery after neural injury. Disconnection of a brain commissure in the nudibranch mollusc, Tritonia diomedea , impairs swimming behavior by eliminating particular synapses in the central pattern generator (CPG) underlying the rhythmic swim motor pattern. However, the CPG functionally recovers within a day after the lesion. The strength of a spared inhibitory synapse within the CPG from Cerebral Neuron 2 (C2) to Ventral Swim Interneuron B (VSI) determines the level of impairment caused by the lesion, which varies among individuals. In addition to this direct synaptic connection, there are polysynaptic connections from C2 and Dorsal Swim Interneurons to VSI that provide indirect excitatory drive but play only minor roles under normal conditions. After disconnecting the pedal commissure (Pedal Nerve 6), the recruitment of polysynaptic excitation became a major source of the excitatory drive to VSI. Moreover, the amount of polysynaptic recruitment, which changed over time, differed among individuals and correlated with the degree of recovery of the swim motor pattern. Thus, functional recovery was mediated by an increase in the magnitude of polysynaptic excitatory drive, compensating for the loss of direct excitation. Since the degree of susceptibility to injury corresponds to existing individual variation in the C2 to VSI synapse, the recovery relied upon the extent to which the network reorganized to incorporate additional synapses." @default.
- W2504268164 created "2016-08-23" @default.
- W2504268164 creator A5006005959 @default.
- W2504268164 creator A5017933300 @default.
- W2504268164 creator A5021497943 @default.
- W2504268164 date "2016-07-01" @default.
- W2504268164 modified "2023-10-13" @default.
- W2504268164 title "Recruitment of Polysynaptic Connections Underlies Functional Recovery of a Neural Circuit after Lesion" @default.
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