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• W2504471065 abstract "The granulopoietic reserve pools of cells in human bone marrow of patients with different hematopoietic disorders are of diagnostic and of prognostic relevance. The prognostic implication includes acute and also chronic neutropenic states. A test for the bone marrow reserve of immature granulopoietic cells in humans has not been established, so far. This presentation describes a novel approach to the clinical assessment of neutropenia and of the reserve pools of leukocyte phenotypes of distinct granulopoietic maturation stages in the bone marrow of humans by application of highly purified humoral (serum-derived) and cellular (leukocytic cytokine) effectors (wound hormones) for operation of leukocytosis and leftward shift reactions. So far, two different, highly purified polypeptide effectors were applied for this purpose in healthy humans and patients with different hematopoietic disorders; to trigger phenotype-selective chemorecruitment of granulocytes of different maturation stages from the bone marrow with subsequent leukocytosis and leftward shift reactions in circulating blood cell patterns for evaluation of neutropenia: Serum-derived leuko-recruitin (SLR, hydrodynamic equivalent of molecular weight: 8500 dalton) and monocyto-metamyelo-recruitin (MMR, hydrodynamic equivalent of molecular weight: 6500 dalton). They were recently obtained in highly purified form from contact-activated porcine serum and from serum-free cultures of technical amounts of isolated, lectin-activated porcine leukocytes (monocytes, macrophage type), respectively. SLR mainly recruits mature, segmented granulocytes from the bone marrow into blood circulation of animals and humans. Thus, it causes a general leukocytosis without a prominent leftward shift reaction. MMR mainly recruits immature (bands and metamyelocytic) granulocytes in concurrence with some myelocytes from the bone marrow into circulation and transiently sequestrates mature segmented leukocytes, i.e. it recruits them from blood circulation into marginal storage pools. Thus, by this dual function, MMR causes a dramatic leftward shift without a general leukocytosis reaction. In healthy humans and patients with different hematopoietic disorders (infantile genetic agranulocytosis, constitutional aplastic anemia and hypersplenic pancytopenia), the responses to SLR resulted three main patterns (termed high, low and non-responder) which correlated with the cellular content of the bone marrow storage pool and clinical outcome. MMR induced a storage pool-dependent increase of immature granulocytes in peripheral blood. Regression analysis results a linear relation between the total number of the different granulocytic phenotypes which are mobilized into blood circulation, and their actual bone marrow reserve assessed. Our results indicate a new, selective effector-operated biochemical method for clinical evaluation of neutropenic states and of cellular reserve pools of leukocytic phenotypes in granulopoiesis of humans by application of highly purified polypeptide wound hormones." @default.
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• W2504471065 date "1985-01-01" @default.
• W2504471065 modified "2023-09-27" @default.
• W2504471065 title "Clinical Assessment of Neutropenia and of Reserve Pools of Leukocyte Phenotypes of Distinct Granulopoietic Maturation Stage in Bone Marrow of Humans by Purified Humoral and Cellular Polypeptide Effectors For Leukocytosis and Lefward Shift Reactions" @default.
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• W2504471065 doi "https://doi.org/10.1016/b978-0-08-031739-7.50286-x" @default.
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