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• W2504472322 abstract "Prior evidence suggests a role for statins in the management of cancer. However, the benefit of statin use in the adjuvant setting remains uncertain. This study investigates associations between statin use initiated after a breast cancer diagnosis and mortality.Women with stage I-III breast cancer were identified from the National Cancer Registry of Ireland (N=4243). Post-diagnostic statin initiators were identified from pharmacy claims data (N=837). Multivariate models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between de novo statin use and mortality.The median duration of statin use was 6.7 years. No association was found between post-diagnostic statin use and breast cancer-specific (HR 0.88, 95% CI 0.66, 1.17) or all-cause mortality (HR 1.00, 95% CI 0.82, 1.21).The results from our study suggest that initiating statin use after a diagnosis of stage I-III breast cancer is not associated with a reduction in breast cancer-specific mortality." @default.
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• W2504472322 date "2016-08-01" @default.
• W2504472322 modified "2023-10-09" @default.
• W2504472322 title "De novo post-diagnosis statin use, breast cancer-specific and overall mortality in women with stage I–III breast cancer" @default.
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• W2504472322 doi "https://doi.org/10.1038/bjc.2016.232" @default.
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