Matches in SemOpenAlex for { <https://semopenalex.org/work/W250451609> ?p ?o ?g. }
- W250451609 endingPage "3136" @default.
- W250451609 startingPage "3129" @default.
- W250451609 abstract "A strong lymphocyte-specific transcriptional enhancer was identified within a DNase I hypersensitive site at the 3' end of the human CD2 gene. Full activity, in a transient expression assay, was contained within a region of 550 bp (minimal enhancer). T cells which express CD2 could use the enhancer to activate transcription from the reporter gene chloramphenicol acetyltransferase in the context of a heterologous promoter. Lower levels of transcription were detected in non-CD2-expressing T cells and in B cells. In contrast, the enhancer did not function in the epithelial cell line HeLa or in Colo 320 HSR, a cell line of neuroendocrine origin. Low levels of enhancement were detectable from two core regions, which acted synergistically with other cis-acting sequences to generate the complete enhancer. DNase I footprinting studies identified six cis-acting sequences to which proteins bound. Five of these sequence motifs were novel; the sixth was a canonical cAMP response element. Topoisomerase II, and scaffold attachment region consensus sequences were also found within an A/T-rich area downstream of the minimal enhancer. Neither region was bound to the nuclear matrix. The CD2 enhancer is modular in structure, it is constructed of novel cis-acting sequences and it is a major component of the regulatory system that controls expression of the CD2 gene." @default.
- W250451609 created "2016-06-24" @default.
- W250451609 creator A5026352442 @default.
- W250451609 creator A5032626789 @default.
- W250451609 creator A5058875110 @default.
- W250451609 date "1990-10-01" @default.
- W250451609 modified "2023-10-06" @default.
- W250451609 title "A 3′ transcriptional enhancer regulates tissue-specific expression of the human CD2 gene." @default.
- W250451609 cites W114060563 @default.
- W250451609 cites W130386237 @default.
- W250451609 cites W1505967628 @default.
- W250451609 cites W1591452120 @default.
- W250451609 cites W1605780775 @default.
- W250451609 cites W1669391357 @default.
- W250451609 cites W1917818589 @default.
- W250451609 cites W1968102722 @default.
- W250451609 cites W1974034312 @default.
- W250451609 cites W1976923063 @default.
- W250451609 cites W1982598173 @default.
- W250451609 cites W1993243592 @default.
- W250451609 cites W2012454894 @default.
- W250451609 cites W2014669590 @default.
- W250451609 cites W2014689788 @default.
- W250451609 cites W2014765246 @default.
- W250451609 cites W2033777731 @default.
- W250451609 cites W2042976701 @default.
- W250451609 cites W2043734426 @default.
- W250451609 cites W2051858658 @default.
- W250451609 cites W2053986287 @default.
- W250451609 cites W2059360369 @default.
- W250451609 cites W2062438194 @default.
- W250451609 cites W2062722074 @default.
- W250451609 cites W2068577315 @default.
- W250451609 cites W2072606138 @default.
- W250451609 cites W2083065209 @default.
- W250451609 cites W2093401651 @default.
- W250451609 cites W2104498491 @default.
- W250451609 cites W2118299921 @default.
- W250451609 cites W2128334381 @default.
- W250451609 cites W2132352426 @default.
- W250451609 cites W2144206181 @default.
- W250451609 cites W2177510297 @default.
- W250451609 cites W2177704086 @default.
- W250451609 cites W2415935410 @default.
- W250451609 cites W42365435 @default.
- W250451609 cites W54744860 @default.
- W250451609 cites W88875626 @default.
- W250451609 doi "https://doi.org/10.1002/j.1460-2075.1990.tb07510.x" @default.
- W250451609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/552041" @default.
- W250451609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2209539" @default.
- W250451609 hasPublicationYear "1990" @default.
- W250451609 type Work @default.
- W250451609 sameAs 250451609 @default.
- W250451609 citedByCount "68" @default.
- W250451609 countsByYear W2504516092013 @default.
- W250451609 countsByYear W2504516092015 @default.
- W250451609 countsByYear W2504516092017 @default.
- W250451609 countsByYear W2504516092023 @default.
- W250451609 crossrefType "journal-article" @default.
- W250451609 hasAuthorship W250451609A5026352442 @default.
- W250451609 hasAuthorship W250451609A5032626789 @default.
- W250451609 hasAuthorship W250451609A5058875110 @default.
- W250451609 hasBestOaLocation W2504516091 @default.
- W250451609 hasConcept C101762097 @default.
- W250451609 hasConcept C104317684 @default.
- W250451609 hasConcept C111936080 @default.
- W250451609 hasConcept C138885662 @default.
- W250451609 hasConcept C143211211 @default.
- W250451609 hasConcept C150194340 @default.
- W250451609 hasConcept C153911025 @default.
- W250451609 hasConcept C161733203 @default.
- W250451609 hasConcept C165864922 @default.
- W250451609 hasConcept C179926584 @default.
- W250451609 hasConcept C182614070 @default.
- W250451609 hasConcept C21592294 @default.
- W250451609 hasConcept C21784809 @default.
- W250451609 hasConcept C2779377703 @default.
- W250451609 hasConcept C2780730277 @default.
- W250451609 hasConcept C3017666073 @default.
- W250451609 hasConcept C41895202 @default.
- W250451609 hasConcept C54355233 @default.
- W250451609 hasConcept C86803240 @default.
- W250451609 hasConceptScore W250451609C101762097 @default.
- W250451609 hasConceptScore W250451609C104317684 @default.
- W250451609 hasConceptScore W250451609C111936080 @default.
- W250451609 hasConceptScore W250451609C138885662 @default.
- W250451609 hasConceptScore W250451609C143211211 @default.
- W250451609 hasConceptScore W250451609C150194340 @default.
- W250451609 hasConceptScore W250451609C153911025 @default.
- W250451609 hasConceptScore W250451609C161733203 @default.
- W250451609 hasConceptScore W250451609C165864922 @default.
- W250451609 hasConceptScore W250451609C179926584 @default.
- W250451609 hasConceptScore W250451609C182614070 @default.
- W250451609 hasConceptScore W250451609C21592294 @default.
- W250451609 hasConceptScore W250451609C21784809 @default.
- W250451609 hasConceptScore W250451609C2779377703 @default.
- W250451609 hasConceptScore W250451609C2780730277 @default.
- W250451609 hasConceptScore W250451609C3017666073 @default.