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• W2504563792 abstract "Lipoprotein(a) (Lp[a]) is a complex of a low-density lipoprotein (LDL)-like particle and apolipoprotein-B100 covalently bound to apolipoprotein (a) (apo[a]). Lp(a) was first described about 50 years ago (1963) by Kare Berg, who found that high serum levels of Lp(a) are inherited and associated with an increased risk of premature cardiovascular disease (CVD)1. Apo(a) is composed of repeated loop-shaped units called kringles, the sequences of which are highly similar to a kringle shape present in the fibrinolytic pro-enzyme plasminogen. Variability in the number of repeated kringle units in the apo(a) molecule gives rise to differently sized Lp(a) isoforms in the population. Based on the similarity of Lp(a) to both LDL and plasminogen, it has been hypothesised that the function of this lipoprotein may represent a link between atherosclerosis and thrombosis. Lp(a) is able to pass through the intima of blood vessels in humans and animals. Accordingly, high plasma levels of Lp(a) may share with LDL atherogenicity, and may stimulate lipid peroxidation and infiltration, smooth muscle cell proliferation and inflammation in the arterial intima in humans." @default.
• W2504563792 created "2016-08-23" @default.
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• W2504563792 date "2016-09-01" @default.
• W2504563792 modified "2023-09-23" @default.
• W2504563792 title "HyperLp(a)lipoproteinaemia: unmet need of diagnosis and treatment?" @default.
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• W2504563792 doi "https://doi.org/10.2450/2016.0027-16" @default.
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