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• W2504633478 startingPage "115" @default.
• W2504633478 abstract "In vertebrates, the heart is the first organ to form during embryonic organogenesis as its function is vital for providing nutrients and removing waste in the rapidly developing embryo. Cardiogenesis represents a highly complex process involving the commitment of distinct cell lineages towards the formation and integration of several precisely patterned modular elements (e.g., atria, ventricles, septa, and valves). The commitment of cell lineages to specific regions of the developing heart and their migration, proliferation, and differentiation require the highly coordinated action of numerous signaling pathways, such as wingless/Int (Wnt), bone morphogenesis protein (BMP), Activin and Nodal, fibroblast growth factor (FGF), Notch, Erb, Hedgehog (Hh), and retinoic acid (RA) cascades. They in turn orchestrate expression of regulatory circuitry of transcription factors, such as Nkx2–5, GATA family zinc finger proteins, T-box (Tbx) factors, and many others. As a result, several distinctive transcriptional programs direct the cell specification, proliferation, and compartmentalization in the developing heart. Over the past decade, microRNAs (miRNAs) have emerged as novel essential regulators of cardiovascular development and disease. Understanding of the molecular mechanisms of the complex process of cardiovascular development is critical for the development of cell-based therapy using embryonic stem cells (ESCs) or cardiac progenitor cells for the treatment children and adults with cardiovascular disease (CVD)." @default.
• W2504633478 created "2016-08-23" @default.
• W2504633478 creator A5022739391 @default.
• W2504633478 date "2014-01-01" @default.
• W2504633478 modified "2023-09-25" @default.
• W2504633478 title "Molecular Determinants of Cardiac Development" @default.
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