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- W2504854013 abstract "In this contribution, we review the molecular and physiological barriers to oral delivery of peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro systems with special emphasis on human intestine in Ussing chambers. First, the molecular constraints to peptide absorption are discussed. Then the physiological barriers to peptide delivery are examined. These include the gastric and intestinal environment, the mucus barrier, tight junctions between epithelial cells, the enterocytes of the intestinal epithelium, and the subepithelial tissue. Recent data from human proteome studies are used to provide information about the protein expression profiles of the different physiological barriers to peptide and nanoparticle absorption. Strategies that have been employed to increase peptide absorption across each of the barriers are discussed. Special consideration is given to attempts at utilizing endogenous transcytotic pathways. To reliably translate in vitro data on peptide or nanoparticle permeability to the in vivo situation in a human subject, the in vitro experimental system needs to realistically capture the central aspects of the mentioned barriers. Therefore, characteristics of common in vitro cell culture systems are discussed and compared to those of human intestinal tissues. Attempts to use the cell and tissue models for in vitro-in vivo extrapolation are reviewed." @default.
- W2504854013 created "2016-08-23" @default.
- W2504854013 creator A5029622436 @default.
- W2504854013 creator A5079220895 @default.
- W2504854013 date "2016-11-01" @default.
- W2504854013 modified "2023-10-17" @default.
- W2504854013 title "Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues" @default.
- W2504854013 cites W1084201805 @default.
- W2504854013 cites W1319875 @default.
- W2504854013 cites W141733981 @default.
- W2504854013 cites W1426172237 @default.
- W2504854013 cites W1466247529 @default.
- W2504854013 cites W1486750235 @default.
- W2504854013 cites W1489601464 @default.
- W2504854013 cites W1502026371 @default.
- W2504854013 cites W1504811282 @default.
- W2504854013 cites W1529881100 @default.
- W2504854013 cites W1537679770 @default.
- W2504854013 cites W1539027279 @default.
- W2504854013 cites W1548863075 @default.
- W2504854013 cites W156207140 @default.
- W2504854013 cites W1564282281 @default.
- W2504854013 cites W1586111803 @default.
- W2504854013 cites W1587638772 @default.
- W2504854013 cites W1596283370 @default.
- W2504854013 cites W1607700524 @default.
- W2504854013 cites W1611441558 @default.
- W2504854013 cites W1850017326 @default.
- W2504854013 cites W1904678284 @default.
- W2504854013 cites W1921478143 @default.
- W2504854013 cites W1939160085 @default.
- W2504854013 cites W1940172037 @default.
- W2504854013 cites W1961430621 @default.
- W2504854013 cites W1963601943 @default.
- W2504854013 cites W1963956821 @default.
- W2504854013 cites W1964381304 @default.
- W2504854013 cites W1967580843 @default.
- W2504854013 cites W1969839658 @default.
- W2504854013 cites W1970424480 @default.
- W2504854013 cites W1971325965 @default.
- W2504854013 cites W1973863973 @default.
- W2504854013 cites W1974477809 @default.
- W2504854013 cites W1974591261 @default.
- W2504854013 cites W1975077715 @default.
- W2504854013 cites W1976600333 @default.
- W2504854013 cites W1976611079 @default.
- W2504854013 cites W1976933509 @default.
- W2504854013 cites W1978224396 @default.
- W2504854013 cites W1978308605 @default.
- W2504854013 cites W1979363781 @default.
- W2504854013 cites W1981195608 @default.
- W2504854013 cites W1983493053 @default.
- W2504854013 cites W1985656429 @default.
- W2504854013 cites W1986023636 @default.
- W2504854013 cites W1986799021 @default.
- W2504854013 cites W1986965232 @default.
- W2504854013 cites W1986977142 @default.
- W2504854013 cites W1990311208 @default.
- W2504854013 cites W1990538137 @default.
- W2504854013 cites W1991151214 @default.
- W2504854013 cites W1993544510 @default.
- W2504854013 cites W1994294415 @default.
- W2504854013 cites W1994584839 @default.
- W2504854013 cites W1994668150 @default.
- W2504854013 cites W1994837626 @default.
- W2504854013 cites W1995139997 @default.
- W2504854013 cites W1996759553 @default.
- W2504854013 cites W1996980152 @default.
- W2504854013 cites W1998963313 @default.
- W2504854013 cites W1999160838 @default.
- W2504854013 cites W1999471314 @default.
- W2504854013 cites W2000422049 @default.
- W2504854013 cites W2001956269 @default.
- W2504854013 cites W2002387722 @default.
- W2504854013 cites W2002936944 @default.
- W2504854013 cites W2003111539 @default.
- W2504854013 cites W2003394211 @default.
- W2504854013 cites W2003572328 @default.
- W2504854013 cites W2004150216 @default.
- W2504854013 cites W2005161126 @default.
- W2504854013 cites W2005971493 @default.
- W2504854013 cites W2007950027 @default.
- W2504854013 cites W2009473148 @default.
- W2504854013 cites W2011337131 @default.
- W2504854013 cites W2011739832 @default.
- W2504854013 cites W2011982742 @default.
- W2504854013 cites W2012034410 @default.
- W2504854013 cites W2012484113 @default.
- W2504854013 cites W2013657751 @default.
- W2504854013 cites W2014272062 @default.
- W2504854013 cites W2015752928 @default.
- W2504854013 cites W2018318303 @default.
- W2504854013 cites W2018445772 @default.
- W2504854013 cites W2018687970 @default.
- W2504854013 cites W2019188597 @default.
- W2504854013 cites W2020100603 @default.
- W2504854013 cites W2020347152 @default.
- W2504854013 cites W2020770450 @default.