FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2504957675> ?p ?o ?g. }

• W2504957675 endingPage "e0159189" @default.
• W2504957675 startingPage "e0159189" @default.
• W2504957675 abstract "Acute myeloid leukemia (AML) is a heterogeneous group of aggressive bone marrow cancers arising from transformed hematopoietic stem and progenitor cells (HSPC). Therapy-related AML and MDS (t-AML/MDS) comprise a subset of AML cases occurring after exposure to alkylating chemotherapy and/or radiation and are associated with a very poor prognosis. Less is known about the pathogenesis and disease-initiating/leukemia stem cell (LSC) subpopulations of t-AML/MDS compared to their de novo counterparts. Here, we report the development of mouse models of t-AML/MDS. First, we modeled alkylator-induced t-AML/MDS by exposing wild type adult mice to N-ethyl-N-nitrosurea (ENU), resulting in several models of AML and MDS that have clinical and pathologic characteristics consistent with human t-AML/MDS including cytopenia, myelodysplasia, and shortened overall survival. These models were limited by their inability to transplant clinically aggressive disease. Second, we established three patient-derived xenograft models of human t-AML. These models led to rapidly fatal disease in recipient immunodeficient xenografted mice. LSC activity was identified in multiple HSPC subpopulations suggesting there is no canonical LSC immunophenotype in human t-AML. Overall, we report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics." @default.
• W2504957675 created "2016-08-23" @default.
• W2504957675 creator A5000141075 @default.
• W2504957675 creator A5068133376 @default.
• W2504957675 creator A5070059120 @default.
• W2504957675 creator A5074919402 @default.
• W2504957675 date "2016-07-18" @default.
• W2504957675 modified "2023-09-27" @default.
• W2504957675 title "Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity" @default.
• W2504957675 cites W1255676896 @default.
• W2504957675 cites W1600262245 @default.
• W2504957675 cites W1843432358 @default.
• W2504957675 cites W1939711593 @default.
• W2504957675 cites W1966719615 @default.
• W2504957675 cites W1967358345 @default.
• W2504957675 cites W1968846332 @default.
• W2504957675 cites W1968949976 @default.
• W2504957675 cites W1979616743 @default.
• W2504957675 cites W1983641075 @default.
• W2504957675 cites W1984882433 @default.
• W2504957675 cites W1988397531 @default.
• W2504957675 cites W1997345775 @default.
• W2504957675 cites W2002213310 @default.
• W2504957675 cites W2009886857 @default.
• W2504957675 cites W20143477 @default.
• W2504957675 cites W2020990571 @default.
• W2504957675 cites W2026721712 @default.
• W2504957675 cites W2027950772 @default.
• W2504957675 cites W2036436976 @default.
• W2504957675 cites W2043169671 @default.
• W2504957675 cites W2046053349 @default.
• W2504957675 cites W2046650031 @default.
• W2504957675 cites W2050127987 @default.
• W2504957675 cites W2054449135 @default.
• W2504957675 cites W2054592620 @default.
• W2504957675 cites W2058917707 @default.
• W2504957675 cites W2063561870 @default.
• W2504957675 cites W2071450234 @default.
• W2504957675 cites W2075877031 @default.
• W2504957675 cites W2076031927 @default.
• W2504957675 cites W2077567802 @default.
• W2504957675 cites W2090757708 @default.
• W2504957675 cites W2090982381 @default.
• W2504957675 cites W2095286549 @default.
• W2504957675 cites W2095486213 @default.
• W2504957675 cites W2097540657 @default.
• W2504957675 cites W2097948293 @default.
• W2504957675 cites W2103930081 @default.
• W2504957675 cites W2107027906 @default.
• W2504957675 cites W2107398329 @default.
• W2504957675 cites W2124789340 @default.
• W2504957675 cites W2126448969 @default.
• W2504957675 cites W2135647037 @default.
• W2504957675 cites W2137419788 @default.
• W2504957675 cites W2138163973 @default.
• W2504957675 cites W2139310798 @default.
• W2504957675 cites W2148965443 @default.
• W2504957675 cites W2149430154 @default.
• W2504957675 cites W2157155777 @default.
• W2504957675 cites W2157783208 @default.
• W2504957675 cites W2163355013 @default.
• W2504957675 cites W2164983190 @default.
• W2504957675 doi "https://doi.org/10.1371/journal.pone.0159189" @default.
• W2504957675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4948781" @default.
• W2504957675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27428079" @default.
• W2504957675 hasPublicationYear "2016" @default.
• W2504957675 type Work @default.
• W2504957675 sameAs 2504957675 @default.
• W2504957675 citedByCount "2" @default.
• W2504957675 countsByYear W25049576752020 @default.
• W2504957675 countsByYear W25049576752022 @default.
• W2504957675 crossrefType "journal-article" @default.
• W2504957675 hasAuthorship W2504957675A5000141075 @default.
• W2504957675 hasAuthorship W2504957675A5068133376 @default.
• W2504957675 hasAuthorship W2504957675A5070059120 @default.
• W2504957675 hasAuthorship W2504957675A5074919402 @default.
• W2504957675 hasBestOaLocation W25049576751 @default.
• W2504957675 hasConcept C109159458 @default.
• W2504957675 hasConcept C142724271 @default.
• W2504957675 hasConcept C196166836 @default.
• W2504957675 hasConcept C201750760 @default.
• W2504957675 hasConcept C203014093 @default.
• W2504957675 hasConcept C2778461978 @default.
• W2504957675 hasConcept C2778729363 @default.
• W2504957675 hasConcept C2779134260 @default.
• W2504957675 hasConcept C2779282312 @default.
• W2504957675 hasConcept C2780007613 @default.
• W2504957675 hasConcept C2780366003 @default.
• W2504957675 hasConcept C2780817109 @default.
• W2504957675 hasConcept C28328180 @default.
• W2504957675 hasConcept C502942594 @default.
• W2504957675 hasConcept C54355233 @default.
• W2504957675 hasConcept C553184892 @default.
• W2504957675 hasConcept C71924100 @default.
• W2504957675 hasConcept C86803240 @default.
• W2504957675 hasConceptScore W2504957675C109159458 @default.
• W2504957675 hasConceptScore W2504957675C142724271 @default.
• W2504957675 hasConceptScore W2504957675C196166836 @default.

• next