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- W2504993638 abstract "Ran is an abundant nuclear GTPase that has been extensively characterized for its role in nuclear transport. The Ran pathway is involved in spindle assembly and postmitotic nuclear assembly, independent of its role in nuclear transport. The distribution of Ran's nucleotide exchange factor (RCC1) and GTPase activating protein (RanGAP1) leads to the formation of gradients of Ran-GTP within the cell. These gradients provide spatial cues that direct Ran-dependent processes. These cues are monitored through a common set of Ran-GTP binding effector proteins that were originally characterized as nuclear transport receptors. The past year has seen a considerable deepening in our understanding of the molecular features of this pathway and of how gradients of Ran-GTP are built and utilized. This chapter relates these new developments to Ran's role in cellular processes." @default.
- W2504993638 created "2016-08-23" @default.
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- W2504993638 creator A5054057454 @default.
- W2504993638 date "2003-01-01" @default.
- W2504993638 modified "2023-09-25" @default.
- W2504993638 title "Cellular Roles of the Ran GTPase" @default.
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- W2504993638 doi "https://doi.org/10.1016/b978-012124546-7/50597-0" @default.
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