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- W2505364110 endingPage "44" @default.
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- W2505364110 abstract "Maintenance of the native DNA sequence and structure is essential for normalfunction and ultimately to survival. DNA damage can result from numerous externalagents and from normal cellular processes. For example, ionizing radiation caninduce single-and double-strand breaks, exposure to UV light can produce pyrimidine dimers, spontaneous depurination or enzyme-mediated base removal canproduce abasic sites, and cytosine deamination can yield a non-native DNAbase-uracil. These lesions produce structural and dynamic changes in DNA, whichimpair its function. In fact, failure to correctly repair DNA damage can result inmutations, cancer, and death. To minimize the detrimental effects of DNA damage,evolution has provided cells with DNA repair systems, each eliminating a differentkind of DNA damage and restoring its normal function." @default.
- W2505364110 created "2016-08-23" @default.
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- W2505364110 date "2005-09-19" @default.
- W2505364110 modified "2023-09-25" @default.
- W2505364110 title "Dynamics of DNA Damage Recognition" @default.
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- W2505364110 doi "https://doi.org/10.1201/9780849352683-5" @default.
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