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• W2505871388 endingPage "8323" @default.
• W2505871388 startingPage "8302" @default.
• W2505871388 abstract "The yeast 2-micron plasmid epitomizes the evolutionary optimization of selfish extra-chromosomal genomes for stable persistence without jeopardizing their hosts’ fitness. Analyses of fluorescence-tagged single-copy reporter plasmids and/or the plasmid partitioning proteins in native and non-native hosts reveal chromosome-hitchhiking as the likely means for plasmid segregation. The contribution of the partitioning system to equal segregation is bipartite- replication-independent and replication-dependent. The former nearly eliminates ‘mother bias’ (preferential plasmid retention in the mother cell) according to binomial distribution, thus limiting equal segregation of a plasmid pair to 50%. The latter enhances equal segregation of plasmid sisters beyond this level, elevating the plasmid close to chromosome status. Host factors involved in plasmid partitioning can be functionally separated by their participation in the replication-independent and/or replication-dependent steps. In the hitchhiking model, random tethering of a pair of plasmids to chromosomes signifies the replication-independent component of segregation; the symmetric tethering of plasmid sisters to sister chromatids embodies the replication-dependent component. The 2-micron circle broadly resembles the episomes of certain mammalian viruses in its chromosome-associated propagation. This unifying feature among otherwise widely differing selfish genomes suggests their evolutionary convergence to the common logic of exploiting, albeit via distinct molecular mechanisms, host chromosome segregation machineries for self-preservation." @default.
• W2505871388 created "2016-08-23" @default.
• W2505871388 creator A5013385312 @default.
• W2505871388 creator A5025404800 @default.
• W2505871388 creator A5046141379 @default.
• W2505871388 creator A5072631702 @default.
• W2505871388 date "2016-08-04" @default.
• W2505871388 modified "2023-10-11" @default.
• W2505871388 title "Replication-dependent and independent mechanisms for the chromosome-coupled persistence of a selfish genome" @default.
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