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- W2505909416 abstract "RNA degradation is tightly regulated to selectively target aberrant RNAs, including viral RNA, but this regulation is incompletely understood. Through RNAi screening in Drosophila cells, we identified the 3′-to-5′ RNA exosome and two components of the exosome cofactor TRAMP (Trf4/5–Air1/2–Mtr4 polyadenylation) complex, dMtr4 and dZcchc7, as antiviral against a panel of RNA viruses. We extended our studies to human orthologs and found that the exosome as well as TRAMP components hMTR4 and hZCCHC7 are antiviral. While hMTR4 and hZCCHC7 are normally nuclear, infection by cytoplasmic RNA viruses induces their export, forming a cytoplasmic complex that specifically recognizes and induces degradation of viral mRNAs. Furthermore, the 3′ untranslated region (UTR) of bunyaviral mRNA is sufficient to confer virus-induced exosomal degradation. Altogether, our results reveal that signals from viral infection repurpose TRAMP components to a cytoplasmic surveillance role where they selectively engage viral RNAs for degradation to restrict a broad range of viruses." @default.
- W2505909416 created "2016-08-23" @default.
- W2505909416 creator A5005387242 @default.
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- W2505909416 creator A5055919781 @default.
- W2505909416 creator A5061185706 @default.
- W2505909416 creator A5076439669 @default.
- W2505909416 date "2016-07-15" @default.
- W2505909416 modified "2023-10-16" @default.
- W2505909416 title "A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation" @default.
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