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- W2505912273 abstract "SUMMARY Thepresenceofembryonic prealbumin (EPA)hasbeenconfirmed infetal fibroblasts, chondrocytes, anddistal tubular epithelial cells byan indirect immunoperoxidase technique. EPA hasoften beenfound also inthestromal cells ofbenign andmalignant mesodermal tumours, butnot intheepithelial cells ofbenign andmalignant epithelial tumours. ThatEPAisnotan exclusive product ofneoplastic mesodermal cells isdemonstrated byour finding ofEPAinfibroblasts of granulation tissue, irradiated fibroblasts, andindistal tubular epithelial cells ofmiscellaneous adult kidneys. Humanembryonic prealbumin (EPA)isarecently described fetal protein whichhasbeenshowntobe non-identical withavariety ofoncofetal antigens, including alphafetoprotein, carcinoembryonic antigen,pregnancy-specific glycoprotein and betaoncofetal antigen.1 Itisa glycoprotein containing 21% carbohydrate andthere aretwoimmunologically identical forms oftheprotein, onehaving a molecular weight of41000,theother 68000.With animmunodiffusion technique, EPAisdetectable in normal fetal serumatanearly stage ofdevelopment, theserumconcentration rising steadily andreaching apeakbetween the20thand30thweekofgestation. Immunodiffusion studies havealsodemonstrated thatitispresent inhomogenates oftumours, especially those ofconnective tissue origin, andin over17different fetal adult fibroblast celllines.2-4 Withthefluorescent antibody technique Kalashnikovandhiscolleagues3 haveshownitcanbe localised within placenta, umbilical cord,fetal tissues (including skin, bone, andkidney) andinthe stromasurrounding someepithelial tumours. In ourstudy, using an indirect immunoperoxidase technique, wehaveexamined formalin-fixed paraffin embedded humanfetal andadulttissues forthe presence anddistribution ofEPA,including benign andmalignant tumours. Inaddition, todetermine whether ornotEPAistruly anoncofetal protein, tissues andorgans frompatients withvarious nonneoplastic conditions werestudied." @default.
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- W2505912273 date "1981-01-01" @default.
- W2505912273 modified "2023-09-27" @default.
- W2505912273 title "Localisation ofembryonic prealbumin informalin- fixed humanfetal andadult tissue" @default.
- W2505912273 hasPublicationYear "1981" @default.
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