FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2505962313> ?p ?o ?g. }

• W2505962313 abstract "Alzheimer’s disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervous system) levels around β-amyloid plaques and neurofibrillary tangles is a common feature of AD neuropathology. Amnesic effects of scopolamine (acetylcholine receptor antagonist) can be investigated in various behavioral tests such as Morris water maze, object recognition, Y-maze, and passive avoidance. In the scope of this paper, we report the anti-AChE, anti-BChE properties of the isolated compound and the in vivo effects of the methanolic extract of Xylia xylocarpa (MEXX) on scopolamine-induced memory deficit. In further phytochemistry study, a new hopan-type triterpenoid, (3β)-hopan-3-ol-28,22-olide (1), together with twenty known compounds were isolated (2–21). Compound 1, 2, 4, 5, 7–9, and 11–13 exhibited potent acetylcholinesterase (AChE) inhibitory activity in a concentration-dependent manner with IC50 values ranging from 54.4 to 94.6 μM. Compound 13 was also shown anti-butyrylcholinesterase (BChE) activity with an IC50 value of 42.7 μM. The Morris water Y-maze, Y-maze, and object recognition test were also carried out. It is noteworthy that MEXX is effective when administered orally to mice, experimental results are consistent with the traditional use of this medicinal plant species." @default.
• W2505962313 created "2016-08-23" @default.
• W2505962313 creator A5004063524 @default.
• W2505962313 creator A5022057431 @default.
• W2505962313 creator A5046569267 @default.
• W2505962313 creator A5051047872 @default.
• W2505962313 creator A5054722786 @default.
• W2505962313 creator A5058301125 @default.
• W2505962313 creator A5059068326 @default.
• W2505962313 creator A5059569662 @default.
• W2505962313 creator A5065373217 @default.
• W2505962313 creator A5074093514 @default.
• W2505962313 creator A5088530131 @default.
• W2505962313 creator A5091629120 @default.
• W2505962313 date "2016-08-03" @default.
• W2505962313 modified "2023-09-26" @default.
• W2505962313 title "Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa" @default.
• W2505962313 cites W151697079 @default.
• W2505962313 cites W1541218967 @default.
• W2505962313 cites W1967247394 @default.
• W2505962313 cites W1971048984 @default.
• W2505962313 cites W1984988243 @default.
• W2505962313 cites W1988245111 @default.
• W2505962313 cites W1992170892 @default.
• W2505962313 cites W1994580609 @default.
• W2505962313 cites W1998121962 @default.
• W2505962313 cites W1998624159 @default.
• W2505962313 cites W1999717818 @default.
• W2505962313 cites W2000040052 @default.
• W2505962313 cites W2003966687 @default.
• W2505962313 cites W2014371439 @default.
• W2505962313 cites W2014822152 @default.
• W2505962313 cites W2021414421 @default.
• W2505962313 cites W2040949523 @default.
• W2505962313 cites W2047451912 @default.
• W2505962313 cites W2056595407 @default.
• W2505962313 cites W2064202574 @default.
• W2505962313 cites W2069180519 @default.
• W2505962313 cites W2075910702 @default.
• W2505962313 cites W2075911624 @default.
• W2505962313 cites W2081010421 @default.
• W2505962313 cites W2087433512 @default.
• W2505962313 cites W2088594661 @default.
• W2505962313 cites W2091973569 @default.
• W2505962313 cites W2120386404 @default.
• W2505962313 cites W2132148176 @default.
• W2505962313 cites W2144050713 @default.
• W2505962313 cites W2157016321 @default.
• W2505962313 cites W2168398266 @default.
• W2505962313 cites W2313447651 @default.
• W2505962313 cites W2477593094 @default.
• W2505962313 cites W4211156109 @default.
• W2505962313 cites W4234060991 @default.
• W2505962313 cites W4253373342 @default.
• W2505962313 doi "https://doi.org/10.1186/s13065-016-0197-5" @default.
• W2505962313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4973094" @default.
• W2505962313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27493681" @default.
• W2505962313 hasPublicationYear "2016" @default.
• W2505962313 type Work @default.
• W2505962313 sameAs 2505962313 @default.
• W2505962313 citedByCount "11" @default.
• W2505962313 countsByYear W25059623132017 @default.
• W2505962313 countsByYear W25059623132019 @default.
• W2505962313 countsByYear W25059623132020 @default.
• W2505962313 countsByYear W25059623132021 @default.
• W2505962313 countsByYear W25059623132022 @default.
• W2505962313 countsByYear W25059623132023 @default.
• W2505962313 crossrefType "journal-article" @default.
• W2505962313 hasAuthorship W2505962313A5004063524 @default.
• W2505962313 hasAuthorship W2505962313A5022057431 @default.
• W2505962313 hasAuthorship W2505962313A5046569267 @default.
• W2505962313 hasAuthorship W2505962313A5051047872 @default.
• W2505962313 hasAuthorship W2505962313A5054722786 @default.
• W2505962313 hasAuthorship W2505962313A5058301125 @default.
• W2505962313 hasAuthorship W2505962313A5059068326 @default.
• W2505962313 hasAuthorship W2505962313A5059569662 @default.
• W2505962313 hasAuthorship W2505962313A5065373217 @default.
• W2505962313 hasAuthorship W2505962313A5074093514 @default.
• W2505962313 hasAuthorship W2505962313A5088530131 @default.
• W2505962313 hasAuthorship W2505962313A5091629120 @default.
• W2505962313 hasBestOaLocation W25059623131 @default.
• W2505962313 hasConcept C150903083 @default.
• W2505962313 hasConcept C15744967 @default.
• W2505962313 hasConcept C169760540 @default.
• W2505962313 hasConcept C181199279 @default.
• W2505962313 hasConcept C185592680 @default.
• W2505962313 hasConcept C207001950 @default.
• W2505962313 hasConcept C22885893 @default.
• W2505962313 hasConcept C2775910092 @default.
• W2505962313 hasConcept C2778816929 @default.
• W2505962313 hasConcept C2779059548 @default.
• W2505962313 hasConcept C2779101902 @default.
• W2505962313 hasConcept C2781161787 @default.
• W2505962313 hasConcept C31896038 @default.
• W2505962313 hasConcept C44752575 @default.
• W2505962313 hasConcept C55493867 @default.
• W2505962313 hasConcept C71924100 @default.
• W2505962313 hasConcept C86803240 @default.
• W2505962313 hasConcept C98274493 @default.
• W2505962313 hasConceptScore W2505962313C150903083 @default.

• next