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• W2506062488 abstract "To explore the association between magnetic resonance imaging (MRI), including Haralick textural features, and biochemical recurrence following prostate cancer radiotherapy.In all, 74 patients with peripheral zone localized prostate adenocarcinoma underwent pretreatment 3.0T MRI before external beam radiotherapy. Median follow-up of 47 months revealed 11 patients with biochemical recurrence. Prostate tumors were segmented on T2 -weighted sequences (T2 -w) and contours were propagated onto the coregistered apparent diffusion coefficient (ADC) images. We extracted 140 image features from normalized T2 -w and ADC images corresponding to first-order (n = 6), gradient-based (n = 4), and second-order Haralick textural features (n = 130). Four geometrical features (tumor diameter, perimeter, area, and volume) were also computed. Correlations between Gleason score and MRI features were assessed. Cox regression analysis and random survival forests (RSF) were performed to assess the association between MRI features and biochemical recurrence.Three T2 -w and one ADC Haralick textural features were significantly correlated with Gleason score (P < 0.05). Twenty-eight T2 -w Haralick features and all four geometrical features were significantly associated with biochemical recurrence (P < 0.05). The most relevant features were Haralick features T2 -w contrast, T2 -w difference variance, ADC median, along with tumor volume and tumor area (C-index from 0.76 to 0.82; P < 0.05). By combining these most powerful features in an RSF model, the obtained C-index was 0.90.T2 -w Haralick features appear to be strongly associated with biochemical recurrence following prostate cancer radiotherapy.3 J. Magn. Reson. Imaging 2017;45:103-117." @default.
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• W2506062488 date "2016-06-27" @default.
• W2506062488 modified "2023-10-06" @default.
• W2506062488 title "Haralick textural features on<i>T</i>₂-weighted MRI are associated with biochemical recurrence following radiotherapy for peripheral zone prostate cancer" @default.
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• W2506062488 doi "https://doi.org/10.1002/jmri.25335" @default.
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