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- W2506067488 abstract "Septic patients with myocardial dysfunction have a 3-fold increase in mortality compared with patients without cardiovascular impairment, and usually show myocarditis, disruption of the contractile apparatus, increased amounts of interstitial collagen, and damaged mitochondria. The presence of nitric oxide and cytokines in cardiac tissue constitute the molecular markers and the intracellular messengers of inflammatory conditions in the heart due to the onset of sepsis and endotoxemia, derived from the nuclear factor-κB pathway activation and proinflammatory gene transcription. Sepsis occurs with an exacerbated inflammatory response that damages tissue mitochondria and impaired bioenergetic processes. The heart consumes 20–30 times its own weight in adenosine triphosphate every day, and 90% of this molecule is derived from mitochondrial oxidative phosphorylation. Cardiac energy management is comprised in sepsis and endotoxemia; both a deficit in energy production and alterations in the source of energy substrates are believed to be involved in impaired cardiac function. Although several hypotheses try to explain the molecular mechanisms underlying the complex condition of sepsis and endotoxemia, the current view is that these syndromes are the result of an intricate balance between prevailing levels of mitochondrial stress, biogenesis/autophagy signaling and mitochondria quality control processes, rather on a single factor. The aim of this review is to discuss current hypothesis of cardiac dysfunction related to energy metabolism and mitochondrial function in experimental models of sepsis and endotoxemia, and to introduce the importance of lipids (mainly cardiolipin) in the mechanism of cardiac energy mismanagement in these inflammatory conditions." @default.
- W2506067488 created "2016-08-23" @default.
- W2506067488 creator A5017328444 @default.
- W2506067488 creator A5039852077 @default.
- W2506067488 creator A5086186209 @default.
- W2506067488 date "2016-12-01" @default.
- W2506067488 modified "2023-10-09" @default.
- W2506067488 title "Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: Interrelated aspects in endotoxemia and sepsis" @default.
- W2506067488 cites W134928204 @default.
- W2506067488 cites W1533489700 @default.
- W2506067488 cites W1537812171 @default.
- W2506067488 cites W1584301804 @default.
- W2506067488 cites W166801957 @default.
- W2506067488 cites W1722845210 @default.
- W2506067488 cites W1830583197 @default.
- W2506067488 cites W1836200479 @default.
- W2506067488 cites W1946896925 @default.
- W2506067488 cites W1965921415 @default.
- W2506067488 cites W1966772446 @default.
- W2506067488 cites W1966778344 @default.
- W2506067488 cites W1969072747 @default.
- W2506067488 cites W1971082641 @default.
- W2506067488 cites W1977376843 @default.
- W2506067488 cites W1981000654 @default.
- W2506067488 cites W1981377319 @default.
- W2506067488 cites W1986568749 @default.
- W2506067488 cites W1988397850 @default.
- W2506067488 cites W1992969522 @default.
- W2506067488 cites W1996120614 @default.
- W2506067488 cites W1996155397 @default.
- W2506067488 cites W1998333201 @default.
- W2506067488 cites W2000263337 @default.
- W2506067488 cites W2001163298 @default.
- W2506067488 cites W2004536137 @default.
- W2506067488 cites W2006919847 @default.
- W2506067488 cites W2008680963 @default.
- W2506067488 cites W2009213152 @default.
- W2506067488 cites W2012898950 @default.
- W2506067488 cites W2017239413 @default.
- W2506067488 cites W2025165424 @default.
- W2506067488 cites W2025477455 @default.
- W2506067488 cites W2026460049 @default.
- W2506067488 cites W2030591331 @default.
- W2506067488 cites W2031643961 @default.
- W2506067488 cites W2033468628 @default.
- W2506067488 cites W2033729587 @default.
- W2506067488 cites W2035988892 @default.
- W2506067488 cites W2037445261 @default.
- W2506067488 cites W2038658195 @default.
- W2506067488 cites W2039440815 @default.
- W2506067488 cites W2039920136 @default.
- W2506067488 cites W2044322051 @default.
- W2506067488 cites W2046706496 @default.
- W2506067488 cites W2051175462 @default.
- W2506067488 cites W2051675665 @default.
- W2506067488 cites W2052833946 @default.
- W2506067488 cites W2056256216 @default.
- W2506067488 cites W2062835892 @default.
- W2506067488 cites W2069525370 @default.
- W2506067488 cites W2071806226 @default.
- W2506067488 cites W2072138622 @default.
- W2506067488 cites W2072950045 @default.
- W2506067488 cites W2076849320 @default.
- W2506067488 cites W2079324010 @default.
- W2506067488 cites W2083822522 @default.
- W2506067488 cites W2093505141 @default.
- W2506067488 cites W2093558980 @default.
- W2506067488 cites W2095444184 @default.
- W2506067488 cites W2095497639 @default.
- W2506067488 cites W2095575219 @default.
- W2506067488 cites W2099281097 @default.
- W2506067488 cites W2101363646 @default.
- W2506067488 cites W2101950940 @default.
- W2506067488 cites W2103654023 @default.
- W2506067488 cites W2104821764 @default.
- W2506067488 cites W2106070017 @default.
- W2506067488 cites W2110056576 @default.
- W2506067488 cites W2113161320 @default.
- W2506067488 cites W2116642215 @default.
- W2506067488 cites W2116729573 @default.
- W2506067488 cites W2119900852 @default.
- W2506067488 cites W2123725650 @default.
- W2506067488 cites W2127236047 @default.
- W2506067488 cites W2128606426 @default.
- W2506067488 cites W2131679083 @default.
- W2506067488 cites W2133037534 @default.
- W2506067488 cites W2139871065 @default.
- W2506067488 cites W2142931701 @default.
- W2506067488 cites W2146565710 @default.
- W2506067488 cites W2152746794 @default.
- W2506067488 cites W2161080023 @default.
- W2506067488 cites W2169144885 @default.
- W2506067488 cites W2170289131 @default.
- W2506067488 cites W2171979283 @default.
- W2506067488 cites W2255691977 @default.
- W2506067488 cites W2395559826 @default.
- W2506067488 cites W2493200454 @default.
- W2506067488 cites W2501352424 @default.