Matches in SemOpenAlex for { <https://semopenalex.org/work/W2506095344> ?p ?o ?g. }
- W2506095344 endingPage "319" @default.
- W2506095344 startingPage "301" @default.
- W2506095344 abstract "Multiple myeloma (MM) is a clonal proliferation of abnormal plasma cells in the bone marrow (BM), associated with a monoclonal protein and end-organ damage. MM originates from a pre-malignant condition, called monoclonal gammopathy of undetermined significance (MGUS) and can progress to an extramedullary disease, termed plasma cell leukemia (PCL), which invades the bloodstream. MM cells manifest a wide spectrum of genomic abnormalities, creating a strong intertumoral heterogeneity. Historically, MM patients have been divided into two subgroups: hyperdiploid cases (with >46 chromosomes) and non-hyperdiploid cases. However, the introduction of novel technologies such as fluorescence in situ hybridization (FISH), array comparative genomic hybridization (aCGH) and sequencing techniques is helping to unveil the complexity of MM genomes. In particular, MM cells present: recurrent translocations which deregulate known oncogenes, such as CCND1, FGFR3-MMSET, c-MAF and MYC, numerous copy number variations (CNVs) including deletion of chromosome 13, deletion of chromosome 17p13, and amplification of chromosome 1q21; and various somatic mutations in genes involved in cancer proliferation (RAS, BRAF, FGFR3), protein homeostasis and RNA processing (FAM46C, DIS3, XBP1 and LRRK2); NF-κB signaling; histone methylation; and tumor suppression (TP53). This chapter will summarize our current knowledge of the MM genomic field, focusing on the different types of abnormalities and their relationship with the phases of disease." @default.
- W2506095344 created "2016-08-23" @default.
- W2506095344 creator A5032464400 @default.
- W2506095344 creator A5034020009 @default.
- W2506095344 creator A5050323670 @default.
- W2506095344 date "2014-01-01" @default.
- W2506095344 modified "2023-09-27" @default.
- W2506095344 title "Genomics in Multiple Myeloma" @default.
- W2506095344 cites W142536220 @default.
- W2506095344 cites W1531879063 @default.
- W2506095344 cites W1554322881 @default.
- W2506095344 cites W1602983699 @default.
- W2506095344 cites W1672219033 @default.
- W2506095344 cites W1720235364 @default.
- W2506095344 cites W180015230 @default.
- W2506095344 cites W1810265271 @default.
- W2506095344 cites W1944291718 @default.
- W2506095344 cites W1965481841 @default.
- W2506095344 cites W1973562447 @default.
- W2506095344 cites W1979036766 @default.
- W2506095344 cites W1980268334 @default.
- W2506095344 cites W1981403111 @default.
- W2506095344 cites W1987148763 @default.
- W2506095344 cites W1989861663 @default.
- W2506095344 cites W1991188105 @default.
- W2506095344 cites W1991899579 @default.
- W2506095344 cites W1993401552 @default.
- W2506095344 cites W1993549070 @default.
- W2506095344 cites W1995832783 @default.
- W2506095344 cites W2000189234 @default.
- W2506095344 cites W2003426156 @default.
- W2506095344 cites W2004834404 @default.
- W2506095344 cites W2006680755 @default.
- W2506095344 cites W2010163650 @default.
- W2506095344 cites W2010552629 @default.
- W2506095344 cites W2010570442 @default.
- W2506095344 cites W2012182672 @default.
- W2506095344 cites W2015077916 @default.
- W2506095344 cites W2021555408 @default.
- W2506095344 cites W2022687427 @default.
- W2506095344 cites W2023007035 @default.
- W2506095344 cites W2023046293 @default.
- W2506095344 cites W2024985626 @default.
- W2506095344 cites W2027359959 @default.
- W2506095344 cites W2027389500 @default.
- W2506095344 cites W2028247160 @default.
- W2506095344 cites W2028330103 @default.
- W2506095344 cites W2029006246 @default.
- W2506095344 cites W2030500412 @default.
- W2506095344 cites W2032058375 @default.
- W2506095344 cites W2033212544 @default.
- W2506095344 cites W2037230945 @default.
- W2506095344 cites W2038477042 @default.
- W2506095344 cites W2041236924 @default.
- W2506095344 cites W2045010580 @default.
- W2506095344 cites W2047221626 @default.
- W2506095344 cites W2048509801 @default.
- W2506095344 cites W2050043316 @default.
- W2506095344 cites W2050453122 @default.
- W2506095344 cites W2053456304 @default.
- W2506095344 cites W2055662838 @default.
- W2506095344 cites W2055927459 @default.
- W2506095344 cites W2058914749 @default.
- W2506095344 cites W2058966655 @default.
- W2506095344 cites W2059963348 @default.
- W2506095344 cites W2063697325 @default.
- W2506095344 cites W2066254965 @default.
- W2506095344 cites W2067653691 @default.
- W2506095344 cites W2072714194 @default.
- W2506095344 cites W2075032656 @default.
- W2506095344 cites W2075175917 @default.
- W2506095344 cites W2079513879 @default.
- W2506095344 cites W2079571107 @default.
- W2506095344 cites W2080164596 @default.
- W2506095344 cites W2080660780 @default.
- W2506095344 cites W2084499660 @default.
- W2506095344 cites W2099334882 @default.
- W2506095344 cites W2100572488 @default.
- W2506095344 cites W2101035019 @default.
- W2506095344 cites W2103101762 @default.
- W2506095344 cites W2104452168 @default.
- W2506095344 cites W2110486997 @default.
- W2506095344 cites W2110648338 @default.
- W2506095344 cites W2113444305 @default.
- W2506095344 cites W2115385885 @default.
- W2506095344 cites W2120572492 @default.
- W2506095344 cites W2126116268 @default.
- W2506095344 cites W2127419185 @default.
- W2506095344 cites W2130664802 @default.
- W2506095344 cites W2133649716 @default.
- W2506095344 cites W2136683006 @default.
- W2506095344 cites W2138102966 @default.
- W2506095344 cites W2139250658 @default.
- W2506095344 cites W2141550675 @default.
- W2506095344 cites W2141639822 @default.
- W2506095344 cites W2143311031 @default.
- W2506095344 cites W2144892629 @default.
- W2506095344 cites W2149877193 @default.