Matches in SemOpenAlex for { <https://semopenalex.org/work/W2506227922> ?p ?o ?g. }
- W2506227922 endingPage "481" @default.
- W2506227922 startingPage "463" @default.
- W2506227922 abstract "Parathyroid hormone is essential for the maintenance of calcium homeostasis through direct actions on its principal target organs, bone and kidney, and through indirect actions on the gastrointestinal tract. Parathyroid hormone acts directly on the skeleton to promote calcium release from bone and on the kidney to enhance calcium reabsorption. The indirect effects of parathyroid hormone on the gastrointestinal tract lead to greater calcium absorption through its actions to facilitate the conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D. Actions of parathyroid hormone at these three sites, the kidney, the skeleton, and the gastrointestinal tract, result in restoration of the extracellular calcium concentration. Parathyroid hormone helps to regulate phosphorus metabolism where an increase in phosphorus leads to a reduction in the circulating calcium concentration. The resultant increase in parathyroid hormone leads to phosphaturia, a classical physiological effect of the hormone and restoration of the serum phosphorus concentration. The principal form of biologically active parathyroid hormone is the intact molecule, PTH-(1–84), whose half-life in the circulation is less than 3 min. Clearance of parathyroid hormone occurs rapidly in the liver (60%–70%), kidney (20%–30%), and to a much lesser extent in other organs. PTH regulates gene expression in the osteoblast, supporting synthesis of matrix proteins required for new bone formation, proteins regulating osteoclast differentiation, and proteins associated with matrix degradation and turnover." @default.
- W2506227922 created "2016-08-23" @default.
- W2506227922 creator A5013126573 @default.
- W2506227922 creator A5060025923 @default.
- W2506227922 creator A5086493873 @default.
- W2506227922 date "2002-01-01" @default.
- W2506227922 modified "2023-09-26" @default.
- W2506227922 title "Actions of Parathyroid Hormone" @default.
- W2506227922 cites W122488193 @default.
- W2506227922 cites W1487918137 @default.
- W2506227922 cites W1499942184 @default.
- W2506227922 cites W1508055754 @default.
- W2506227922 cites W1509836111 @default.
- W2506227922 cites W1512359172 @default.
- W2506227922 cites W1515324823 @default.
- W2506227922 cites W1524345526 @default.
- W2506227922 cites W1536059021 @default.
- W2506227922 cites W1541704381 @default.
- W2506227922 cites W1576643759 @default.
- W2506227922 cites W1577673639 @default.
- W2506227922 cites W1578229516 @default.
- W2506227922 cites W1599501164 @default.
- W2506227922 cites W1603002960 @default.
- W2506227922 cites W1894408874 @default.
- W2506227922 cites W1962070166 @default.
- W2506227922 cites W1964661085 @default.
- W2506227922 cites W1964905329 @default.
- W2506227922 cites W1965635765 @default.
- W2506227922 cites W1966447383 @default.
- W2506227922 cites W1968814931 @default.
- W2506227922 cites W1969999796 @default.
- W2506227922 cites W1970861121 @default.
- W2506227922 cites W1970867711 @default.
- W2506227922 cites W1971482740 @default.
- W2506227922 cites W1971815893 @default.
- W2506227922 cites W1972745909 @default.
- W2506227922 cites W1972861607 @default.
- W2506227922 cites W1976318249 @default.
- W2506227922 cites W1977013832 @default.
- W2506227922 cites W1979462438 @default.
- W2506227922 cites W1979744776 @default.
- W2506227922 cites W1981197836 @default.
- W2506227922 cites W1982150046 @default.
- W2506227922 cites W1983116459 @default.
- W2506227922 cites W1983167142 @default.
- W2506227922 cites W1983950276 @default.
- W2506227922 cites W1984110276 @default.
- W2506227922 cites W1986350744 @default.
- W2506227922 cites W1986487519 @default.
- W2506227922 cites W1987679215 @default.
- W2506227922 cites W1988463358 @default.
- W2506227922 cites W1989006435 @default.
- W2506227922 cites W1989106910 @default.
- W2506227922 cites W1989631152 @default.
- W2506227922 cites W1991674531 @default.
- W2506227922 cites W1992184028 @default.
- W2506227922 cites W1992349853 @default.
- W2506227922 cites W1993566504 @default.
- W2506227922 cites W1994449766 @default.
- W2506227922 cites W1994577070 @default.
- W2506227922 cites W1996164381 @default.
- W2506227922 cites W1996211818 @default.
- W2506227922 cites W1998034203 @default.
- W2506227922 cites W1998056221 @default.
- W2506227922 cites W1998577613 @default.
- W2506227922 cites W1998862606 @default.
- W2506227922 cites W1999480762 @default.
- W2506227922 cites W2001930850 @default.
- W2506227922 cites W2003727255 @default.
- W2506227922 cites W2004018263 @default.
- W2506227922 cites W2005008381 @default.
- W2506227922 cites W2005086919 @default.
- W2506227922 cites W2005258782 @default.
- W2506227922 cites W2006566021 @default.
- W2506227922 cites W2006611546 @default.
- W2506227922 cites W2006632162 @default.
- W2506227922 cites W2007716744 @default.
- W2506227922 cites W2009897801 @default.
- W2506227922 cites W2010447377 @default.
- W2506227922 cites W2011033582 @default.
- W2506227922 cites W2012066024 @default.
- W2506227922 cites W2013242641 @default.
- W2506227922 cites W2015247179 @default.
- W2506227922 cites W2015686697 @default.
- W2506227922 cites W2016032320 @default.
- W2506227922 cites W2016939563 @default.
- W2506227922 cites W2017309664 @default.
- W2506227922 cites W2018602999 @default.
- W2506227922 cites W2019479109 @default.
- W2506227922 cites W2019545214 @default.
- W2506227922 cites W2021626407 @default.
- W2506227922 cites W2022700397 @default.
- W2506227922 cites W2022764813 @default.
- W2506227922 cites W2025014029 @default.
- W2506227922 cites W2026446264 @default.
- W2506227922 cites W2028011522 @default.
- W2506227922 cites W2029132947 @default.
- W2506227922 cites W2030285552 @default.