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- W2506368049 abstract "80 MHz 31P NMR and 400 MHz 1H spin-echo NMR are used to compare and contrast reactions of aurothiomalate (Myocrisin) Et3PAuCl, and Et3PAu(TATG), where TATG is 2,3,4,6-tetra-0-acetyl-1-thio-B-D-glucopyranosato-S, (auranofin) with intact red blood cells, glutathione in model reactions, and dimercaptopropanol (dmp), an agent thought to be useful for reversal of gold toxicity. The hydrophobic phosphine complexes readily penetrate cells, and their exchange reactions are more rapid on the NMR timescale than those of aurothiomalate. In red cells, Et3PAuCl is partitioned between GSH and a second site, and (Et3P)2Au+ is also formed at high Au levels. Significant Et3P release and oxidation to OPEt3 is observed inside cells only when dmp is added. (Et3P)2Au+ is not auranofin-treated red cells. We also show that auranofin, when added to whole blood, is partitioned between plasma and cells. It is suggested that a key feature in the molecular pharmacology of gold(I) is its ability to transport, store, and release reducing equivalents (thiols and phosphines)." @default.
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- W2506368049 date "1983-01-26" @default.
- W2506368049 modified "2023-10-03" @default.
- W2506368049 title "Ligand Exchange Reactions of Gold Drugs in Model Systems and in Red Cells" @default.
- W2506368049 doi "https://doi.org/10.1021/bk-1983-0209.ch019" @default.
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