Matches in SemOpenAlex for { <https://semopenalex.org/work/W2506423325> ?p ?o ?g. }
- W2506423325 endingPage "1412" @default.
- W2506423325 startingPage "1399" @default.
- W2506423325 abstract "Aim: Fungi are valuable resources for bioactive secondary metabolites. However, the chemical space of fungal secondary metabolites has been studied only on a limited basis. Herein, we report a comprehensive chemoinformatic analysis of a unique set of 207 fungal metabolites isolated and characterized in a USA National Cancer Institute funded drug discovery project. Results: Comparison of the molecular complexity of the 207 fungal metabolites with approved anticancer and nonanticancer drugs, compounds in clinical studies, general screening compounds and molecules Generally Recognized as Safe revealed that fungal metabolites have high degree of complexity. Molecular fingerprints showed that fungal metabolites are as structurally diverse as other natural products and have, in general, drug-like physicochemical properties. Conclusion: Fungal products represent promising candidates to expand the medicinally relevant chemical space. This work is a significant expansion of an analysis reported years ago for a smaller set of compounds (less than half of the ones included in the present work) from filamentous fungi using different structural properties." @default.
- W2506423325 created "2016-08-23" @default.
- W2506423325 creator A5004654043 @default.
- W2506423325 creator A5011810695 @default.
- W2506423325 creator A5016310012 @default.
- W2506423325 creator A5032004586 @default.
- W2506423325 creator A5049755131 @default.
- W2506423325 creator A5053777609 @default.
- W2506423325 creator A5056511678 @default.
- W2506423325 creator A5060499961 @default.
- W2506423325 creator A5086421148 @default.
- W2506423325 date "2016-08-01" @default.
- W2506423325 modified "2023-09-30" @default.
- W2506423325 title "Chemoinformatic expedition of the chemical space of fungal products" @default.
- W2506423325 cites W1493055596 @default.
- W2506423325 cites W1836211944 @default.
- W2506423325 cites W1896078930 @default.
- W2506423325 cites W1968105489 @default.
- W2506423325 cites W1971527053 @default.
- W2506423325 cites W1971849220 @default.
- W2506423325 cites W1974431490 @default.
- W2506423325 cites W1983248350 @default.
- W2506423325 cites W1987758370 @default.
- W2506423325 cites W1988037271 @default.
- W2506423325 cites W1991833480 @default.
- W2506423325 cites W1991931105 @default.
- W2506423325 cites W1998338360 @default.
- W2506423325 cites W2005714501 @default.
- W2506423325 cites W2018518196 @default.
- W2506423325 cites W2020257352 @default.
- W2506423325 cites W2036831677 @default.
- W2506423325 cites W2037843616 @default.
- W2506423325 cites W2039965018 @default.
- W2506423325 cites W2040954367 @default.
- W2506423325 cites W2051553786 @default.
- W2506423325 cites W2057117299 @default.
- W2506423325 cites W2059811616 @default.
- W2506423325 cites W2061741442 @default.
- W2506423325 cites W2063577652 @default.
- W2506423325 cites W2074274985 @default.
- W2506423325 cites W2075043416 @default.
- W2506423325 cites W2077091040 @default.
- W2506423325 cites W2080456521 @default.
- W2506423325 cites W2102876723 @default.
- W2506423325 cites W2110153780 @default.
- W2506423325 cites W2111115182 @default.
- W2506423325 cites W2121360698 @default.
- W2506423325 cites W2126662293 @default.
- W2506423325 cites W2131055502 @default.
- W2506423325 cites W2132445915 @default.
- W2506423325 cites W213318935 @default.
- W2506423325 cites W2151039023 @default.
- W2506423325 cites W2157132743 @default.
- W2506423325 cites W2164120866 @default.
- W2506423325 cites W2256742438 @default.
- W2506423325 cites W2272700231 @default.
- W2506423325 cites W915151961 @default.
- W2506423325 doi "https://doi.org/10.4155/fmc-2016-0079" @default.
- W2506423325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5558535" @default.
- W2506423325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27485744" @default.
- W2506423325 hasPublicationYear "2016" @default.
- W2506423325 type Work @default.
- W2506423325 sameAs 2506423325 @default.
- W2506423325 citedByCount "39" @default.
- W2506423325 countsByYear W25064233252016 @default.
- W2506423325 countsByYear W25064233252017 @default.
- W2506423325 countsByYear W25064233252018 @default.
- W2506423325 countsByYear W25064233252019 @default.
- W2506423325 countsByYear W25064233252020 @default.
- W2506423325 countsByYear W25064233252021 @default.
- W2506423325 countsByYear W25064233252022 @default.
- W2506423325 countsByYear W25064233252023 @default.
- W2506423325 crossrefType "journal-article" @default.
- W2506423325 hasAuthorship W2506423325A5004654043 @default.
- W2506423325 hasAuthorship W2506423325A5011810695 @default.
- W2506423325 hasAuthorship W2506423325A5016310012 @default.
- W2506423325 hasAuthorship W2506423325A5032004586 @default.
- W2506423325 hasAuthorship W2506423325A5049755131 @default.
- W2506423325 hasAuthorship W2506423325A5053777609 @default.
- W2506423325 hasAuthorship W2506423325A5056511678 @default.
- W2506423325 hasAuthorship W2506423325A5060499961 @default.
- W2506423325 hasAuthorship W2506423325A5086421148 @default.
- W2506423325 hasBestOaLocation W25064233252 @default.
- W2506423325 hasConcept C185592680 @default.
- W2506423325 hasConcept C2780035454 @default.
- W2506423325 hasConcept C55493867 @default.
- W2506423325 hasConcept C70721500 @default.
- W2506423325 hasConcept C74187038 @default.
- W2506423325 hasConcept C86803240 @default.
- W2506423325 hasConcept C98274493 @default.
- W2506423325 hasConcept C99726746 @default.
- W2506423325 hasConceptScore W2506423325C185592680 @default.
- W2506423325 hasConceptScore W2506423325C2780035454 @default.
- W2506423325 hasConceptScore W2506423325C55493867 @default.
- W2506423325 hasConceptScore W2506423325C70721500 @default.
- W2506423325 hasConceptScore W2506423325C74187038 @default.
- W2506423325 hasConceptScore W2506423325C86803240 @default.
- W2506423325 hasConceptScore W2506423325C98274493 @default.