FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2506460411> ?p ?o ?g. }

• W2506460411 abstract "Background: Reduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART).The association between immune activation and thymic function in asymptomatic HIV positive treatment-naive individuals has thus far not been investigated.Aims and objectives: To optimise a five-colour flow cytometric assay for measurement of thymic function by measuring recent thymic emigrants (RTEs) in treatment-naive HIV-infected patients and healthy controls and correlate results with levels of immune activation, CD4 counts and viral load.Methods: Blood obtained from 53 consenting HIV-positive individuals and 32 controls recruited from HIV prevention and testing clinic in Cape Town, South Africa. RTEs were measured (CD3+/CD4+/CD45RA+/CD31+/CD62L+) and levels were correlated with CD4 counts of HIV-infected individuals, log viral load and levels of immune activation (CD8+/CD38+ T-cells).Results: HIV-infected individuals had reduced frequencies of RTEs when compared to controls (p = 0.0035). Levels of immune activation were inversely correlated with thymic function(p = 0.0403), and the thymic function in HIV-infected individuals showed no significant correlation with CD4 counts (p = 0.31559) and viral load (p = 0.20628).Conclusions: There was impaired thymic function in HIV-infected individuals, which was associated with increased levels of immune activation. The thymic dysfunction was not associated with CD4 counts and viral load. Immune activation may result in inflammatory damage to the thymus and subsequent thymic dysfunction, and CD4 counts and viral load may not necessarily reflect thymic dysfunction in HIV." @default.
• W2506460411 created "2016-08-23" @default.
• W2506460411 creator A5003594416 @default.
• W2506460411 creator A5036888590 @default.
• W2506460411 creator A5073033574 @default.
• W2506460411 date "2016-07-28" @default.
• W2506460411 modified "2023-10-02" @default.
• W2506460411 title "Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV-infected individuals" @default.
• W2506460411 cites W1534589294 @default.
• W2506460411 cites W1596192963 @default.
• W2506460411 cites W1986355431 @default.
• W2506460411 cites W1999924197 @default.
• W2506460411 cites W2001383225 @default.
• W2506460411 cites W2003071165 @default.
• W2506460411 cites W2008150979 @default.
• W2506460411 cites W2010686257 @default.
• W2506460411 cites W2016836061 @default.
• W2506460411 cites W2023160238 @default.
• W2506460411 cites W2025028670 @default.
• W2506460411 cites W2028402895 @default.
• W2506460411 cites W2035569066 @default.
• W2506460411 cites W2057117085 @default.
• W2506460411 cites W2057459783 @default.
• W2506460411 cites W2059293789 @default.
• W2506460411 cites W2064597790 @default.
• W2506460411 cites W2082702668 @default.
• W2506460411 cites W2083459010 @default.
• W2506460411 cites W2097861892 @default.
• W2506460411 cites W2099088219 @default.
• W2506460411 cites W2099698731 @default.
• W2506460411 cites W2102145741 @default.
• W2506460411 cites W2110289042 @default.
• W2506460411 cites W2115603688 @default.
• W2506460411 cites W2132882100 @default.
• W2506460411 cites W2134361139 @default.
• W2506460411 cites W2136129810 @default.
• W2506460411 cites W2147410424 @default.
• W2506460411 cites W2166653928 @default.
• W2506460411 cites W2171907379 @default.
• W2506460411 cites W2314916731 @default.
• W2506460411 cites W2315236452 @default.
• W2506460411 cites W2329281458 @default.
• W2506460411 cites W2336143018 @default.
• W2506460411 cites W2406997024 @default.
• W2506460411 cites W4233713544 @default.
• W2506460411 doi "https://doi.org/10.4102/sajhivmed.v17i1.445" @default.
• W2506460411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5843076" @default.
• W2506460411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29568606" @default.
• W2506460411 hasPublicationYear "2016" @default.
• W2506460411 type Work @default.
• W2506460411 sameAs 2506460411 @default.
• W2506460411 citedByCount "6" @default.
• W2506460411 countsByYear W25064604112017 @default.
• W2506460411 countsByYear W25064604112019 @default.
• W2506460411 countsByYear W25064604112020 @default.
• W2506460411 countsByYear W25064604112021 @default.
• W2506460411 countsByYear W25064604112023 @default.
• W2506460411 crossrefType "journal-article" @default.
• W2506460411 hasAuthorship W2506460411A5003594416 @default.
• W2506460411 hasAuthorship W2506460411A5036888590 @default.
• W2506460411 hasAuthorship W2506460411A5073033574 @default.
• W2506460411 hasBestOaLocation W25064604111 @default.
• W2506460411 hasConcept C10205521 @default.
• W2506460411 hasConcept C126322002 @default.
• W2506460411 hasConcept C142462285 @default.
• W2506460411 hasConcept C159912055 @default.
• W2506460411 hasConcept C167672396 @default.
• W2506460411 hasConcept C203014093 @default.
• W2506460411 hasConcept C2777910003 @default.
• W2506460411 hasConcept C2780648854 @default.
• W2506460411 hasConcept C28328180 @default.
• W2506460411 hasConcept C2909287720 @default.
• W2506460411 hasConcept C3013748606 @default.
• W2506460411 hasConcept C3020391436 @default.
• W2506460411 hasConcept C54355233 @default.
• W2506460411 hasConcept C71924100 @default.
• W2506460411 hasConcept C86803240 @default.
• W2506460411 hasConcept C8891405 @default.
• W2506460411 hasConceptScore W2506460411C10205521 @default.
• W2506460411 hasConceptScore W2506460411C126322002 @default.
• W2506460411 hasConceptScore W2506460411C142462285 @default.
• W2506460411 hasConceptScore W2506460411C159912055 @default.
• W2506460411 hasConceptScore W2506460411C167672396 @default.
• W2506460411 hasConceptScore W2506460411C203014093 @default.
• W2506460411 hasConceptScore W2506460411C2777910003 @default.
• W2506460411 hasConceptScore W2506460411C2780648854 @default.
• W2506460411 hasConceptScore W2506460411C28328180 @default.
• W2506460411 hasConceptScore W2506460411C2909287720 @default.
• W2506460411 hasConceptScore W2506460411C3013748606 @default.
• W2506460411 hasConceptScore W2506460411C3020391436 @default.
• W2506460411 hasConceptScore W2506460411C54355233 @default.
• W2506460411 hasConceptScore W2506460411C71924100 @default.
• W2506460411 hasConceptScore W2506460411C86803240 @default.
• W2506460411 hasConceptScore W2506460411C8891405 @default.
• W2506460411 hasIssue "1" @default.
• W2506460411 hasLocation W25064604111 @default.
• W2506460411 hasLocation W25064604112 @default.
• W2506460411 hasLocation W25064604113 @default.
• W2506460411 hasLocation W25064604114 @default.
• W2506460411 hasLocation W25064604115 @default.

• next