FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2506770108> ?p ?o ?g. }

• W2506770108 abstract "Pancreatic cancer is an aggressive type of cancer with poor prognosis and low five-year survival rate. Current treatments such as chemotherapy and radiation therapy are not effective. Thus, new therapeutic strategies are urgently needed to treat patients with this devastating disease and to improve their prognosis. Carbon nanotubes (CNTs) constitute a novel nanomaterial extensively studied to develop and exploit their potential in biomedical applications (e.g. drug delivery vehicles and diagnostic agents), including cancer nanobiomedicine. Modification of CNTs with functional groups may improve their aqueous solubility and selectively facilitate the attachment of drugs as well as macromolecules to CNTs, thereby creating new avenues for designing novel and highly targeted drugs. Even though the putative cytotoxicity of functionalized and non-functionalized CNTs is poorly understood, it can be gainfully exploited to enhance the efficacy of anti-cancer drugs. The aim is this study is to investigate the hypothesis that functionalized and non-functionalized CNTs exert differential cytotoxic effects on pancreatic cancer cells. We employed the MTT assay to determine the effects of functionalized and non-functionalized short multi-wall carbon nanotubes (SMWCNTs) on survival of PANC1 cells and Western-blot analysis to elucidate some of the cell survival/proliferation mechanisms (e.g., ERG) underlying the effects induced by SMWCNTs. We used the Seahorse XFp technology to examine the effects of the SMWCNTs on cellular energetics (especially glycolysis & mitochondrial metabolism) in pancreatic cancer cells. Additionally, we employed Annexin V/PI staining in combination with flow cytometry to determine the effects of SMWCNTs in inducing apoptosis in MiaPaca-2 cells. Dose-response studies on pancreatic cancer cells using the MTT assay indicated non-functionalized CNTs to be more cytotoxic than functionalized CNTs. Cell signaling studies indicate no alteration in AKT & phospho-AKT levels between functionalized & non-functionalized CNTs treatment. However, phospho-ERK levels were observed to consistently decrease with increasing concentrations of non-functionalized CNTs. Flow cytometric analysis showed increased apoptotic cell death with non-functionalized CNTs relative to that with functionalized CNTs. Overall, results from these studies indicate the differential effects of CNTs (functionalized versus non-functionalized) on pancreatic cancer cells and as such they may have implications in designing novel therapies for treatment of pancreatic cancer. Citation Format: Alok Bhushan, Rutika Kokate, Vilas Desai, Annie Chhun, Gagan Kaushal, Yao Zhang, James Lai. Differential effects of functionalized and non-functionalized short multi-wall carbon nanotubes on survival of pancreatic cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-049." @default.
• W2506770108 created "2016-08-23" @default.
• W2506770108 creator A5000506692 @default.
• W2506770108 creator A5005006294 @default.
• W2506770108 creator A5007483467 @default.
• W2506770108 creator A5015636197 @default.
• W2506770108 creator A5033555611 @default.
• W2506770108 creator A5046835429 @default.
• W2506770108 creator A5080577523 @default.
• W2506770108 date "2016-07-15" @default.
• W2506770108 modified "2023-09-22" @default.
• W2506770108 title "Abstract LB-049: Differential effects of functionalized and non-functionalized short multi-wall carbon nanotubes on survival of pancreatic cancer cells" @default.
• W2506770108 doi "https://doi.org/10.1158/1538-7445.am2016-lb-049" @default.
• W2506770108 hasPublicationYear "2016" @default.
• W2506770108 type Work @default.
• W2506770108 sameAs 2506770108 @default.
• W2506770108 citedByCount "0" @default.
• W2506770108 crossrefType "proceedings-article" @default.
• W2506770108 hasAuthorship W2506770108A5000506692 @default.
• W2506770108 hasAuthorship W2506770108A5005006294 @default.
• W2506770108 hasAuthorship W2506770108A5007483467 @default.
• W2506770108 hasAuthorship W2506770108A5015636197 @default.
• W2506770108 hasAuthorship W2506770108A5033555611 @default.
• W2506770108 hasAuthorship W2506770108A5046835429 @default.
• W2506770108 hasAuthorship W2506770108A5080577523 @default.
• W2506770108 hasConcept C109316439 @default.
• W2506770108 hasConcept C121608353 @default.
• W2506770108 hasConcept C126322002 @default.
• W2506770108 hasConcept C171250308 @default.
• W2506770108 hasConcept C185592680 @default.
• W2506770108 hasConcept C190283241 @default.
• W2506770108 hasConcept C192562407 @default.
• W2506770108 hasConcept C202751555 @default.
• W2506770108 hasConcept C2780210213 @default.
• W2506770108 hasConcept C2780783641 @default.
• W2506770108 hasConcept C502942594 @default.
• W2506770108 hasConcept C55493867 @default.
• W2506770108 hasConcept C62112901 @default.
• W2506770108 hasConcept C71924100 @default.
• W2506770108 hasConcept C96232424 @default.
• W2506770108 hasConcept C98274493 @default.
• W2506770108 hasConceptScore W2506770108C109316439 @default.
• W2506770108 hasConceptScore W2506770108C121608353 @default.
• W2506770108 hasConceptScore W2506770108C126322002 @default.
• W2506770108 hasConceptScore W2506770108C171250308 @default.
• W2506770108 hasConceptScore W2506770108C185592680 @default.
• W2506770108 hasConceptScore W2506770108C190283241 @default.
• W2506770108 hasConceptScore W2506770108C192562407 @default.
• W2506770108 hasConceptScore W2506770108C202751555 @default.
• W2506770108 hasConceptScore W2506770108C2780210213 @default.
• W2506770108 hasConceptScore W2506770108C2780783641 @default.
• W2506770108 hasConceptScore W2506770108C502942594 @default.
• W2506770108 hasConceptScore W2506770108C55493867 @default.
• W2506770108 hasConceptScore W2506770108C62112901 @default.
• W2506770108 hasConceptScore W2506770108C71924100 @default.
• W2506770108 hasConceptScore W2506770108C96232424 @default.
• W2506770108 hasConceptScore W2506770108C98274493 @default.
• W2506770108 hasLocation W25067701081 @default.
• W2506770108 hasOpenAccess W2506770108 @default.
• W2506770108 hasPrimaryLocation W25067701081 @default.
• W2506770108 hasRelatedWork W1979283436 @default.
• W2506770108 hasRelatedWork W1989116570 @default.
• W2506770108 hasRelatedWork W2009521631 @default.
• W2506770108 hasRelatedWork W2023782245 @default.
• W2506770108 hasRelatedWork W2114055896 @default.
• W2506770108 hasRelatedWork W2148489388 @default.
• W2506770108 hasRelatedWork W2319732577 @default.
• W2506770108 hasRelatedWork W2329147848 @default.
• W2506770108 hasRelatedWork W2335008747 @default.
• W2506770108 hasRelatedWork W2410702605 @default.
• W2506770108 hasRelatedWork W2592634675 @default.
• W2506770108 hasRelatedWork W2769922296 @default.
• W2506770108 hasRelatedWork W2889402530 @default.
• W2506770108 hasRelatedWork W2906145481 @default.
• W2506770108 hasRelatedWork W2963828268 @default.
• W2506770108 hasRelatedWork W2981409885 @default.
• W2506770108 hasRelatedWork W2988296040 @default.
• W2506770108 hasRelatedWork W3010141237 @default.
• W2506770108 hasRelatedWork W3174953398 @default.
• W2506770108 hasRelatedWork W3202373659 @default.
• W2506770108 isParatext "false" @default.
• W2506770108 isRetracted "false" @default.
• W2506770108 magId "2506770108" @default.
• W2506770108 workType "article" @default.