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- W2506953075 abstract "Hematopoietic stem cells (HSCs) are unique and highly specialized cells that are responsible for replenishing both the entire hematopoietic system and the HSC pool. As the largest cellular organ in mammals, the blood system is constantly being regenerated to meet the demands of the organism, and it is tightly controlled to maintain homeostasis. Within the past decade microRNAs, or miRNAs, have been identified as important regulators of gene expression, and recent research has demonstrated their involvement in hematopoiesis and hematopoietic stem cell biology. This chapter highlights this involvement and describes how specific miRNAs direct specific aspects of hematopoietic stem cell physiology. It also addresses the therapeutic potential of manipulating miRNA levels to treat HSC-based diseases and thus their potential in regenerative medicine." @default.
- W2506953075 created "2016-08-23" @default.
- W2506953075 creator A5035059671 @default.
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- W2506953075 date "2015-01-01" @default.
- W2506953075 modified "2023-09-26" @default.
- W2506953075 title "MicroRNAs in Hematopoietic Stem Cell Biology" @default.
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- W2506953075 doi "https://doi.org/10.1016/b978-0-12-405544-5.00013-7" @default.
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