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- W2507044849 abstract "This chapter discusses that the cell membrane exerts tight control over the contractile machinery during the process of excitation–contraction coupling. Some drugs and toxins exert primary or secondary effects on the electrical properties of the cell membrane and, therefore, exert effects on automaticity, arrhythmias, and force of contraction. It is necessary to understand the electrical properties and behavior of the cell membrane at rest and during excitation to understand the mode of action of therapeutic drugs, toxic agents, neurotransmitters, hormones, and plasma electrolytes on the electrical and mechanical activity of the muscle. The chapter examines the electrical properties of nerve and muscle cells at rest, including the origin of the resting membrane potential (Em). The resting Em and action potential (AP) result from properties of the cell membrane and the ion distributions across it. The transmembrane potential in resting nerve and muscle cells varies with the type of cell. Moreover, the existence of the resting potential enables APs to produce in those types of cells that have excitability." @default.
- W2507044849 created "2016-08-23" @default.
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- W2507044849 date "1995-01-01" @default.
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- W2507044849 title "Origin of Resting Membrane Potentials**Adapted and reprinted by permission from the author's chapter 3 in PHYSIOLOGY (Sperelakis, N. and Banks, R. O., Editors). Copyright © 1993 by Nicholas Sperelakis and Robert O. Banks. Published by Little, Brown and Company." @default.
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- W2507044849 doi "https://doi.org/10.1016/b978-0-12-656970-4.50012-9" @default.
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