FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507300004> ?p ?o ?g. }

• W2507300004 endingPage "609" @default.
• W2507300004 startingPage "601" @default.
• W2507300004 abstract "Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the spinal cord injury by inhibiting the inflammation and improve recovery after spinal cord injury. We have previously demonstrated that exogenous VEGF has neurotrophic effects on injured spinal nerves in organotypic spinal cord slice cultures. However, the mechanisms underlying the neurite growth by exogenous VEGF remain to be explored in spinal cord. In this study, we found out that exogenous VEGF mediated axonal outgrowth through VEGF receptor 1 (VEGFR1) and VEGFR2, both of which were expressed on organotypic spinal cord slices. Although VEGFR1 and VEGFR2 were constitutively expressed in some cells of control spinal cord slices, VEGF treatment upregulated expression of VEGFR1 and VEGFR2. Both VEGFR1 and VEGFR2 were expressed in neuronal cells as well as glial cells of organotypic spinal cord slices. We also observed that VEGF-induced axonal outgrowth was attenuated by a specific mitogen-activated protein kinase (MAPK) inhibitor PD98059 and a specific phosphoinositide 3-kinase (PI3K) inhibitor wortmannin. Thus, these findings suggest that these MAPK and PI3K pathways have important roles in regulating VEGF-induced axonal outgrowth in the postnatal spinal cord." @default.
• W2507300004 created "2016-09-16" @default.
• W2507300004 creator A5048460457 @default.
• W2507300004 creator A5068785484 @default.
• W2507300004 creator A5072547453 @default.
• W2507300004 date "2016-10-01" @default.
• W2507300004 modified "2023-09-26" @default.
• W2507300004 title "Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2" @default.
• W2507300004 cites W1533817008 @default.
• W2507300004 cites W1566509581 @default.
• W2507300004 cites W1587020653 @default.
• W2507300004 cites W1894493322 @default.
• W2507300004 cites W1968706291 @default.
• W2507300004 cites W1970476447 @default.
• W2507300004 cites W1971915141 @default.
• W2507300004 cites W1980969801 @default.
• W2507300004 cites W1981829804 @default.
• W2507300004 cites W1983763042 @default.
• W2507300004 cites W1984869034 @default.
• W2507300004 cites W1988602754 @default.
• W2507300004 cites W2000292756 @default.
• W2507300004 cites W2026320744 @default.
• W2507300004 cites W2029482740 @default.
• W2507300004 cites W2037831265 @default.
• W2507300004 cites W2042592151 @default.
• W2507300004 cites W2042635405 @default.
• W2507300004 cites W2046441900 @default.
• W2507300004 cites W2055240008 @default.
• W2507300004 cites W2056840154 @default.
• W2507300004 cites W2059176107 @default.
• W2507300004 cites W2072182561 @default.
• W2507300004 cites W2084947524 @default.
• W2507300004 cites W2092093968 @default.
• W2507300004 cites W2093490616 @default.
• W2507300004 cites W2103189452 @default.
• W2507300004 cites W2119513113 @default.
• W2507300004 cites W2130731229 @default.
• W2507300004 cites W2141957935 @default.
• W2507300004 cites W2143888795 @default.
• W2507300004 cites W2145116035 @default.
• W2507300004 cites W2151898394 @default.
• W2507300004 cites W768948580 @default.
• W2507300004 doi "https://doi.org/10.1007/s13770-016-0051-9" @default.
• W2507300004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170841" @default.
• W2507300004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30603441" @default.
• W2507300004 hasPublicationYear "2016" @default.
• W2507300004 type Work @default.
• W2507300004 sameAs 2507300004 @default.
• W2507300004 citedByCount "6" @default.
• W2507300004 countsByYear W25073000042019 @default.
• W2507300004 countsByYear W25073000042020 @default.
• W2507300004 countsByYear W25073000042021 @default.
• W2507300004 countsByYear W25073000042022 @default.
• W2507300004 countsByYear W25073000042023 @default.
• W2507300004 crossrefType "journal-article" @default.
• W2507300004 hasAuthorship W2507300004A5048460457 @default.
• W2507300004 hasAuthorship W2507300004A5068785484 @default.
• W2507300004 hasAuthorship W2507300004A5072547453 @default.
• W2507300004 hasBestOaLocation W25073000042 @default.
• W2507300004 hasConcept C113246987 @default.
• W2507300004 hasConcept C126322002 @default.
• W2507300004 hasConcept C146285616 @default.
• W2507300004 hasConcept C14858245 @default.
• W2507300004 hasConcept C167734588 @default.
• W2507300004 hasConcept C169760540 @default.
• W2507300004 hasConcept C170493617 @default.
• W2507300004 hasConcept C184235292 @default.
• W2507300004 hasConcept C202751555 @default.
• W2507300004 hasConcept C2777025900 @default.
• W2507300004 hasConcept C2778308172 @default.
• W2507300004 hasConcept C2778334475 @default.
• W2507300004 hasConcept C2778423431 @default.
• W2507300004 hasConcept C2780394083 @default.
• W2507300004 hasConcept C2780775167 @default.
• W2507300004 hasConcept C502942594 @default.
• W2507300004 hasConcept C55493867 @default.
• W2507300004 hasConcept C57074206 @default.
• W2507300004 hasConcept C62478195 @default.
• W2507300004 hasConcept C71924100 @default.
• W2507300004 hasConcept C86554907 @default.
• W2507300004 hasConcept C86803240 @default.
• W2507300004 hasConcept C95444343 @default.
• W2507300004 hasConceptScore W2507300004C113246987 @default.
• W2507300004 hasConceptScore W2507300004C126322002 @default.
• W2507300004 hasConceptScore W2507300004C146285616 @default.
• W2507300004 hasConceptScore W2507300004C14858245 @default.
• W2507300004 hasConceptScore W2507300004C167734588 @default.
• W2507300004 hasConceptScore W2507300004C169760540 @default.
• W2507300004 hasConceptScore W2507300004C170493617 @default.
• W2507300004 hasConceptScore W2507300004C184235292 @default.
• W2507300004 hasConceptScore W2507300004C202751555 @default.
• W2507300004 hasConceptScore W2507300004C2777025900 @default.
• W2507300004 hasConceptScore W2507300004C2778308172 @default.
• W2507300004 hasConceptScore W2507300004C2778334475 @default.
• W2507300004 hasConceptScore W2507300004C2778423431 @default.
• W2507300004 hasConceptScore W2507300004C2780394083 @default.
• W2507300004 hasConceptScore W2507300004C2780775167 @default.
• W2507300004 hasConceptScore W2507300004C502942594 @default.

• next