FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507312114> ?p ?o ?g. }

• W2507312114 endingPage "4563" @default.
• W2507312114 startingPage "4551" @default.
• W2507312114 abstract "Metastatic disease is responsible for the majority of endocrine cancer deaths. New therapeutic targets are urgently needed to improve patient survival rates. The proto-oncogene PTTG1-binding factor (PBF/PTTG1IP) is overexpressed in multiple endocrine cancers and circumstantially associated with tumor aggressiveness. This study aimed to understand the role of PBF in tumor cell invasion and identify possible routes to inhibit its action. Thyroid, breast, and colorectal cells were transfected with PBF and cultured for in vitro analysis. PBF and cortactin (CTTN) expression was determined in differentiated thyroid cancer and The Cancer Genome Atlas RNA-seq data. Pro-invasive effects of PBF were evaluated by 2D Boyden chamber, 3D organotypic, and proximity ligation assays. Our study identified that PBF and CTTN physically interact and co-localize, and that this occurs at the cell periphery, particularly at the leading edge of migrating cancer cells. Critically, PBF induces potent cellular invasion and migration in thyroid and breast cancer cells, which is entirely abrogated in the absence of CTTN. Importantly, we found that CTTN is over-expressed in differentiated thyroid cancer, particularly in patients with regional lymph node metastasis, which significantly correlates with elevated PBF expression. Mutation of PBF (Y174A) or pharmacological intervention modulates the PBF: CTTN interaction and attenuates the invasive properties of cancer cells. Our results demonstrate a unique role for PBF in regulating CTTN function to promote endocrine cell invasion and migration, as well as identify a new targetable interaction to block tumor cell movement." @default.
• W2507312114 created "2016-09-16" @default.
• W2507312114 creator A5002699074 @default.
• W2507312114 creator A5008121589 @default.
• W2507312114 creator A5015317444 @default.
• W2507312114 creator A5019646420 @default.
• W2507312114 creator A5029635272 @default.
• W2507312114 creator A5031305555 @default.
• W2507312114 creator A5032221701 @default.
• W2507312114 creator A5032301342 @default.
• W2507312114 creator A5043445659 @default.
• W2507312114 creator A5044533695 @default.
• W2507312114 creator A5050260397 @default.
• W2507312114 creator A5055292180 @default.
• W2507312114 creator A5065948625 @default.
• W2507312114 creator A5066667381 @default.
• W2507312114 creator A5083885111 @default.
• W2507312114 creator A5085166736 @default.
• W2507312114 date "2016-12-01" @default.
• W2507312114 modified "2023-10-14" @default.
• W2507312114 title "Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin" @default.
• W2507312114 cites W1506176015 @default.
• W2507312114 cites W1519901358 @default.
• W2507312114 cites W1970083958 @default.
• W2507312114 cites W1974009908 @default.
• W2507312114 cites W1975618077 @default.
• W2507312114 cites W1977880258 @default.
• W2507312114 cites W1981880564 @default.
• W2507312114 cites W2001224271 @default.
• W2507312114 cites W2008202147 @default.
• W2507312114 cites W2009009539 @default.
• W2507312114 cites W2013001348 @default.
• W2507312114 cites W2016921443 @default.
• W2507312114 cites W2018186668 @default.
• W2507312114 cites W2023987075 @default.
• W2507312114 cites W2026260372 @default.
• W2507312114 cites W2026292627 @default.
• W2507312114 cites W2032905675 @default.
• W2507312114 cites W2039325880 @default.
• W2507312114 cites W2045537654 @default.
• W2507312114 cites W2055184980 @default.
• W2507312114 cites W2058123533 @default.
• W2507312114 cites W2072941725 @default.
• W2507312114 cites W2081787725 @default.
• W2507312114 cites W2085981486 @default.
• W2507312114 cites W2086540224 @default.
• W2507312114 cites W2088113311 @default.
• W2507312114 cites W2110124055 @default.
• W2507312114 cites W2111656898 @default.
• W2507312114 cites W2112116378 @default.
• W2507312114 cites W2114780363 @default.
• W2507312114 cites W2114843025 @default.
• W2507312114 cites W2125782175 @default.
• W2507312114 cites W2126450377 @default.
• W2507312114 cites W2126496496 @default.
• W2507312114 cites W2134250079 @default.
• W2507312114 cites W2143468862 @default.
• W2507312114 cites W2147545245 @default.
• W2507312114 cites W2149441684 @default.
• W2507312114 cites W2253992243 @default.
• W2507312114 cites W2319486227 @default.
• W2507312114 doi "https://doi.org/10.1210/jc.2016-1932" @default.
• W2507312114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5155689" @default.
• W2507312114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27603901" @default.
• W2507312114 hasPublicationYear "2016" @default.
• W2507312114 type Work @default.
• W2507312114 sameAs 2507312114 @default.
• W2507312114 citedByCount "9" @default.
• W2507312114 countsByYear W25073121142017 @default.
• W2507312114 countsByYear W25073121142018 @default.
• W2507312114 countsByYear W25073121142019 @default.
• W2507312114 countsByYear W25073121142020 @default.
• W2507312114 countsByYear W25073121142022 @default.
• W2507312114 countsByYear W25073121142023 @default.
• W2507312114 crossrefType "journal-article" @default.
• W2507312114 hasAuthorship W2507312114A5002699074 @default.
• W2507312114 hasAuthorship W2507312114A5008121589 @default.
• W2507312114 hasAuthorship W2507312114A5015317444 @default.
• W2507312114 hasAuthorship W2507312114A5019646420 @default.
• W2507312114 hasAuthorship W2507312114A5029635272 @default.
• W2507312114 hasAuthorship W2507312114A5031305555 @default.
• W2507312114 hasAuthorship W2507312114A5032221701 @default.
• W2507312114 hasAuthorship W2507312114A5032301342 @default.
• W2507312114 hasAuthorship W2507312114A5043445659 @default.
• W2507312114 hasAuthorship W2507312114A5044533695 @default.
• W2507312114 hasAuthorship W2507312114A5050260397 @default.
• W2507312114 hasAuthorship W2507312114A5055292180 @default.
• W2507312114 hasAuthorship W2507312114A5065948625 @default.
• W2507312114 hasAuthorship W2507312114A5066667381 @default.
• W2507312114 hasAuthorship W2507312114A5083885111 @default.
• W2507312114 hasAuthorship W2507312114A5085166736 @default.
• W2507312114 hasBestOaLocation W25073121141 @default.
• W2507312114 hasConcept C121608353 @default.
• W2507312114 hasConcept C126322002 @default.
• W2507312114 hasConcept C142669718 @default.
• W2507312114 hasConcept C1491633281 @default.
• W2507312114 hasConcept C2776000893 @default.
• W2507312114 hasConcept C2779013556 @default.

• next