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- W2507318740 abstract "BKU (a sustained release formulation of urapidil) 15, 30, and 60 mg and prazosin1 mg were orally administered consecutively at 1-week intervals to 6 healthy malevolunteers to compare their pharmacokinetic and pharmacological profiles.Both the time to maximum plasma concentration (tmax) and the biological half-lifet(1/2) were longer for BKU than for prazosin. Supine blood pressure decreasedsignificantly after BKU, but not after prazosin. Supine pulse rate increased significantlyafter both drugs. A significant decrease of blood pressure was induced by change ofposition from supine to 50° tilt after both drugs, although no such alteration was inducedbefore drug administration. The exercise-induced elevation of systolic blood pressurewas diminished and the rise of heart rate was enhanced after both drugs.It is concluded that the pharmacokinetic profiles and mode of action of BKU aresimilar to prazosin except for longer tmax and t1/2 in BKU." @default.
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- W2507318740 date "1987-01-01" @default.
- W2507318740 modified "2023-10-04" @default.
- W2507318740 title "Pharmacokinetic and pharmacological effects of urapidil in healthy volunteers. Comparative study with prazosin." @default.
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- W2507318740 doi "https://doi.org/10.3999/jscpt.18.407" @default.
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