FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507330284> ?p ?o ?g. }

• W2507330284 endingPage "311" @default.
• W2507330284 startingPage "303" @default.
• W2507330284 abstract "The endocrine mechanisms that lead to initiation of parturition in dogs are still not fully understood. The prepartum luteolysis is associated with increased prostaglandin (PG) F2α secretion; however, there is no pregnancy- or parturition-related increase in estrogens. Moreover, unlike in other mammalian species, in the dog, increased peripartum levels of cortisol measured sporadically in maternal peripheral blood are not mandatory for normal parturition. Nevertheless, auto/paracrine effects of cortisol at the placental feto-maternal level cannot be excluded. Therefore, the aim of this study was to investigate the expression and localization of glucocorticoid receptor (GR/NR3C1) in canine utero/placental (Ut/Pl) units and uterine interplacental sites at selected time points during pregnancy (pre-implantation, post-implantation and mid-gestation), and at normal and antigestagen-induced parturition. The Ut/Pl expression of GR/NR3C1 did not change significantly from pre-implantation until mid-gestation; however, it was strongly induced during the prepartum luteolysis. Within the interplacental samples, expression of GR/NR3C1-mRNA was greater post-implantation than pre-implantation and did not change afterward, i.e. toward mid-gestation. Compartmentalization studies within the Ut/Pl units, involving placenta, endometrium and myometrium separately, performed at the prepartum luteolysis revealed the highest GR/NR3C1-mRNA levels in placenta compared with endometrium and myometrium. Interestingly, in antigestagen-treated mid-pregnancy dogs, Ut/Pl and interplacental GR/NR3C1-mRNA expression remained unaffected. At the cellular level, placental GR/NR3C1 was clearly detectable in placenta fetalis, i.e. in trophoblast cells. In conclusion, increased expression of GR/NR3C1 during normal parturition, but not following antigestagen-treatment, suggest that it is not required for initiating the signaling cascade of PG synthesis leading to the induction of parturition in the dog." @default.
• W2507330284 created "2016-09-16" @default.
• W2507330284 creator A5004738772 @default.
• W2507330284 creator A5056681714 @default.
• W2507330284 creator A5061519007 @default.
• W2507330284 creator A5076871282 @default.
• W2507330284 date "2016-10-01" @default.
• W2507330284 modified "2023-09-25" @default.
• W2507330284 title "Elevated utero/placental GR/NR3C1 is not required for the induction of parturition in the dog" @default.
• W2507330284 cites W1966065469 @default.
• W2507330284 cites W1970539601 @default.
• W2507330284 cites W1973774144 @default.
• W2507330284 cites W1973965945 @default.
• W2507330284 cites W1984236331 @default.
• W2507330284 cites W1984852534 @default.
• W2507330284 cites W1986369126 @default.
• W2507330284 cites W1986980684 @default.
• W2507330284 cites W1987039281 @default.
• W2507330284 cites W1989835351 @default.
• W2507330284 cites W1992621930 @default.
• W2507330284 cites W1999271186 @default.
• W2507330284 cites W2002413591 @default.
• W2507330284 cites W2003886709 @default.
• W2507330284 cites W2006864976 @default.
• W2507330284 cites W2013514730 @default.
• W2507330284 cites W2016592454 @default.
• W2507330284 cites W2017699467 @default.
• W2507330284 cites W2021825233 @default.
• W2507330284 cites W2024420248 @default.
• W2507330284 cites W2030056935 @default.
• W2507330284 cites W2033054630 @default.
• W2507330284 cites W2035869952 @default.
• W2507330284 cites W2042380511 @default.
• W2507330284 cites W2042676048 @default.
• W2507330284 cites W2049912478 @default.
• W2507330284 cites W2052310540 @default.
• W2507330284 cites W2056499759 @default.
• W2507330284 cites W2067349870 @default.
• W2507330284 cites W2069211405 @default.
• W2507330284 cites W2073430052 @default.
• W2507330284 cites W2076065642 @default.
• W2507330284 cites W2080066625 @default.
• W2507330284 cites W2081832283 @default.
• W2507330284 cites W2081944757 @default.
• W2507330284 cites W2084009240 @default.
• W2507330284 cites W2085000169 @default.
• W2507330284 cites W2100529111 @default.
• W2507330284 cites W2115057904 @default.
• W2507330284 cites W2115670377 @default.
• W2507330284 cites W2115776708 @default.
• W2507330284 cites W2120126426 @default.
• W2507330284 cites W2128801555 @default.
• W2507330284 cites W2128992432 @default.
• W2507330284 cites W2129745229 @default.
• W2507330284 cites W2139834032 @default.
• W2507330284 cites W2142980049 @default.
• W2507330284 cites W2153768794 @default.
• W2507330284 cites W2257550402 @default.
• W2507330284 cites W2415935485 @default.
• W2507330284 cites W2469428313 @default.
• W2507330284 cites W4241267458 @default.
• W2507330284 cites W4253985390 @default.
• W2507330284 cites W983821623 @default.
• W2507330284 doi "https://doi.org/10.1530/rep-16-0213" @default.
• W2507330284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27530348" @default.
• W2507330284 hasPublicationYear "2016" @default.
• W2507330284 type Work @default.
• W2507330284 sameAs 2507330284 @default.
• W2507330284 citedByCount "9" @default.
• W2507330284 countsByYear W25073302842016 @default.
• W2507330284 countsByYear W25073302842019 @default.
• W2507330284 countsByYear W25073302842020 @default.
• W2507330284 countsByYear W25073302842021 @default.
• W2507330284 countsByYear W25073302842022 @default.
• W2507330284 countsByYear W25073302842023 @default.
• W2507330284 crossrefType "journal-article" @default.
• W2507330284 hasAuthorship W2507330284A5004738772 @default.
• W2507330284 hasAuthorship W2507330284A5056681714 @default.
• W2507330284 hasAuthorship W2507330284A5061519007 @default.
• W2507330284 hasAuthorship W2507330284A5076871282 @default.
• W2507330284 hasBestOaLocation W25073302841 @default.
• W2507330284 hasConcept C126322002 @default.
• W2507330284 hasConcept C134018914 @default.
• W2507330284 hasConcept C16685009 @default.
• W2507330284 hasConcept C172680121 @default.
• W2507330284 hasConcept C201614185 @default.
• W2507330284 hasConcept C2776608385 @default.
• W2507330284 hasConcept C2776953305 @default.
• W2507330284 hasConcept C2777330693 @default.
• W2507330284 hasConcept C2777495146 @default.
• W2507330284 hasConcept C2778164554 @default.
• W2507330284 hasConcept C2778324911 @default.
• W2507330284 hasConcept C2779066055 @default.
• W2507330284 hasConcept C2779234561 @default.
• W2507330284 hasConcept C2779742232 @default.
• W2507330284 hasConcept C32253518 @default.
• W2507330284 hasConcept C46973012 @default.
• W2507330284 hasConcept C54355233 @default.

• next