FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507339802> ?p ?o ?g. }

• W2507339802 endingPage "2220" @default.
• W2507339802 startingPage "2212" @default.
• W2507339802 abstract "Abstract Purpose Despite similarities in upfront treatment of childhood cancer, not every adult survivor of childhood cancer (CCS) has an impaired bone mineral density (BMD). No data are available on the role of genetic variation on impairment of BMD in CCS. Methods This cross‐sectional single‐center cohort study included 334 adult CCSs (median follow‐up time after cessation of treatment: 15 years; median age at follow‐up: 26 years). Total body BMD (BMD TB ) and lumbar spine BMD (BMD LS ) were measured by dual x‐ray absorptiometry. We selected 12 candidate single‐nucleotide polymorphisms (SNPs) in 11 genes ( COL1A1, TNFSF11, TNFRSF11, TNRFSA11B, VDR, ESR1, WLS, LRP5, MTHFR, MTRR, IL‐6 ). Results Multivariate analyses revealed that lower BMD was associated with lower weight and height at follow‐up, male sex, and previously administered radiotherapy. Survivors with the homozygous minor allele (GG) genotype of rs2504063 ( ESR1 : estrogen receptor type 1) had a lower BMD TB values (–1.16 vs. –0.82; P = 0.01) than those with the AG/AA genotype; however, BMD LS was not different. Carriers of two minor alleles (GG) of rs599083 ( LRP5 : low‐density lipoprotein receptor) revealed lower BMD TB (–1.20 vs. –0.78; P = 0.02) and lower BMD LS (–0.95 vs. –0.46; P = 0.01) values than those with the TT/TG genotype. Conclusion CCSs who are carriers of candidate SNPs in the ESR1 or LRP5 genes seem to have an impaired bone mass at an early adult age. Information on genetic variation, in addition to patient‐ and treatment‐related factors, may be helpful in identifying survivors who are at risk for low bone density after childhood cancer treatment." @default.
• W2507339802 created "2016-09-16" @default.
• W2507339802 creator A5031530236 @default.
• W2507339802 creator A5035292815 @default.
• W2507339802 creator A5035945818 @default.
• W2507339802 creator A5046291019 @default.
• W2507339802 creator A5081186868 @default.
• W2507339802 creator A5087231343 @default.
• W2507339802 date "2016-08-31" @default.
• W2507339802 modified "2023-10-08" @default.
• W2507339802 title "Genetic variation and bone mineral density in long-term adult survivors of childhood cancer" @default.
• W2507339802 cites W1824933106 @default.
• W2507339802 cites W1967426004 @default.
• W2507339802 cites W1972354950 @default.
• W2507339802 cites W1975526193 @default.
• W2507339802 cites W1981554514 @default.
• W2507339802 cites W1984486655 @default.
• W2507339802 cites W1995172003 @default.
• W2507339802 cites W2010625993 @default.
• W2507339802 cites W2012380150 @default.
• W2507339802 cites W2020955666 @default.
• W2507339802 cites W2021131499 @default.
• W2507339802 cites W2024726068 @default.
• W2507339802 cites W2025233865 @default.
• W2507339802 cites W2033150603 @default.
• W2507339802 cites W2035559267 @default.
• W2507339802 cites W2036767052 @default.
• W2507339802 cites W2037046278 @default.
• W2507339802 cites W2040645421 @default.
• W2507339802 cites W2040956950 @default.
• W2507339802 cites W2047532129 @default.
• W2507339802 cites W2057335882 @default.
• W2507339802 cites W2065766094 @default.
• W2507339802 cites W2071974207 @default.
• W2507339802 cites W2104570606 @default.
• W2507339802 cites W2106782951 @default.
• W2507339802 cites W2110334171 @default.
• W2507339802 cites W2112309180 @default.
• W2507339802 cites W2147017584 @default.
• W2507339802 cites W2149512462 @default.
• W2507339802 cites W2156683209 @default.
• W2507339802 cites W2159287547 @default.
• W2507339802 cites W2160859576 @default.
• W2507339802 cites W2161729741 @default.
• W2507339802 cites W2167858830 @default.
• W2507339802 cites W2170285284 @default.
• W2507339802 cites W2320438909 @default.
• W2507339802 cites W2039918245 @default.
• W2507339802 doi "https://doi.org/10.1002/pbc.26198" @default.
• W2507339802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27578188" @default.
• W2507339802 hasPublicationYear "2016" @default.
• W2507339802 type Work @default.
• W2507339802 sameAs 2507339802 @default.
• W2507339802 citedByCount "7" @default.
• W2507339802 countsByYear W25073398022018 @default.
• W2507339802 countsByYear W25073398022019 @default.
• W2507339802 countsByYear W25073398022020 @default.
• W2507339802 countsByYear W25073398022021 @default.
• W2507339802 countsByYear W25073398022022 @default.
• W2507339802 crossrefType "journal-article" @default.
• W2507339802 hasAuthorship W2507339802A5031530236 @default.
• W2507339802 hasAuthorship W2507339802A5035292815 @default.
• W2507339802 hasAuthorship W2507339802A5035945818 @default.
• W2507339802 hasAuthorship W2507339802A5046291019 @default.
• W2507339802 hasAuthorship W2507339802A5081186868 @default.
• W2507339802 hasAuthorship W2507339802A5087231343 @default.
• W2507339802 hasConcept C104317684 @default.
• W2507339802 hasConcept C124490489 @default.
• W2507339802 hasConcept C126322002 @default.
• W2507339802 hasConcept C134018914 @default.
• W2507339802 hasConcept C135763542 @default.
• W2507339802 hasConcept C143998085 @default.
• W2507339802 hasConcept C153209595 @default.
• W2507339802 hasConcept C157410074 @default.
• W2507339802 hasConcept C179639408 @default.
• W2507339802 hasConcept C2776541429 @default.
• W2507339802 hasConcept C2776886416 @default.
• W2507339802 hasConcept C42407357 @default.
• W2507339802 hasConcept C54355233 @default.
• W2507339802 hasConcept C71924100 @default.
• W2507339802 hasConcept C72563966 @default.
• W2507339802 hasConcept C86803240 @default.
• W2507339802 hasConceptScore W2507339802C104317684 @default.
• W2507339802 hasConceptScore W2507339802C124490489 @default.
• W2507339802 hasConceptScore W2507339802C126322002 @default.
• W2507339802 hasConceptScore W2507339802C134018914 @default.
• W2507339802 hasConceptScore W2507339802C135763542 @default.
• W2507339802 hasConceptScore W2507339802C143998085 @default.
• W2507339802 hasConceptScore W2507339802C153209595 @default.
• W2507339802 hasConceptScore W2507339802C157410074 @default.
• W2507339802 hasConceptScore W2507339802C179639408 @default.
• W2507339802 hasConceptScore W2507339802C2776541429 @default.
• W2507339802 hasConceptScore W2507339802C2776886416 @default.
• W2507339802 hasConceptScore W2507339802C42407357 @default.
• W2507339802 hasConceptScore W2507339802C54355233 @default.
• W2507339802 hasConceptScore W2507339802C71924100 @default.
• W2507339802 hasConceptScore W2507339802C72563966 @default.
• W2507339802 hasConceptScore W2507339802C86803240 @default.

• next