Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507350431> ?p ?o ?g. }
- W2507350431 endingPage "1339" @default.
- W2507350431 startingPage "1339" @default.
- W2507350431 abstract "This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell lines. In contrast, sulphonamide based tamsulosin did not exhibit these effects. In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa. Mechanistically the cytotoxic and antitumor effects of the α-antagonists appear largely independent of α 1-blockade. The proposed targets include: VEGF, EGFR, HER2/Neu, caspase 8/3, topoisomerase 1 and other mitochondrial apoptotic inducing factors. These cytotoxic effects could not be evaluated in human studies as prospective trial data is lacking. However, retrospective studies show a decreased incidence of PCa in males exposed to α-antagonists. As human data evaluating the use of α-antagonists as treatments are lacking; well designed, prospective clinical trials are needed to conclusively demonstrate the anticancer properties of quinazoline based α-antagonists in PCa and other cancers." @default.
- W2507350431 created "2016-09-16" @default.
- W2507350431 creator A5001522343 @default.
- W2507350431 creator A5017776584 @default.
- W2507350431 creator A5023899232 @default.
- W2507350431 creator A5028708552 @default.
- W2507350431 creator A5030930839 @default.
- W2507350431 creator A5038178382 @default.
- W2507350431 creator A5064297077 @default.
- W2507350431 creator A5072182729 @default.
- W2507350431 creator A5078595322 @default.
- W2507350431 creator A5079466083 @default.
- W2507350431 creator A5083630049 @default.
- W2507350431 date "2016-08-16" @default.
- W2507350431 modified "2023-09-26" @default.
- W2507350431 title "The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers" @default.
- W2507350431 cites W109614840 @default.
- W2507350431 cites W1486952607 @default.
- W2507350431 cites W1498865094 @default.
- W2507350431 cites W1505739568 @default.
- W2507350431 cites W1574566086 @default.
- W2507350431 cites W1576438855 @default.
- W2507350431 cites W1640337403 @default.
- W2507350431 cites W1744983296 @default.
- W2507350431 cites W1786131321 @default.
- W2507350431 cites W1848218163 @default.
- W2507350431 cites W1911812329 @default.
- W2507350431 cites W1919351463 @default.
- W2507350431 cites W1930270875 @default.
- W2507350431 cites W1964694459 @default.
- W2507350431 cites W1965843957 @default.
- W2507350431 cites W1980244461 @default.
- W2507350431 cites W1988737917 @default.
- W2507350431 cites W1989821474 @default.
- W2507350431 cites W2000199416 @default.
- W2507350431 cites W2004604946 @default.
- W2507350431 cites W2005611806 @default.
- W2507350431 cites W2006038635 @default.
- W2507350431 cites W2009811269 @default.
- W2507350431 cites W2012753554 @default.
- W2507350431 cites W2013057231 @default.
- W2507350431 cites W2014407855 @default.
- W2507350431 cites W2014813829 @default.
- W2507350431 cites W2025315044 @default.
- W2507350431 cites W2029281434 @default.
- W2507350431 cites W2029548356 @default.
- W2507350431 cites W2033425477 @default.
- W2507350431 cites W2036117421 @default.
- W2507350431 cites W2037135581 @default.
- W2507350431 cites W2037966912 @default.
- W2507350431 cites W2044961565 @default.
- W2507350431 cites W2051289613 @default.
- W2507350431 cites W2054543612 @default.
- W2507350431 cites W2057645408 @default.
- W2507350431 cites W2058883847 @default.
- W2507350431 cites W2058888886 @default.
- W2507350431 cites W2068115015 @default.
- W2507350431 cites W2070080171 @default.
- W2507350431 cites W2070278982 @default.
- W2507350431 cites W2073988927 @default.
- W2507350431 cites W2075529011 @default.
- W2507350431 cites W2077606276 @default.
- W2507350431 cites W2080664740 @default.
- W2507350431 cites W2081433330 @default.
- W2507350431 cites W2084762005 @default.
- W2507350431 cites W2089569798 @default.
- W2507350431 cites W2095105058 @default.
- W2507350431 cites W2095151261 @default.
- W2507350431 cites W2096660146 @default.
- W2507350431 cites W2097122501 @default.
- W2507350431 cites W2099948782 @default.
- W2507350431 cites W2104271783 @default.
- W2507350431 cites W2111728310 @default.
- W2507350431 cites W2122602527 @default.
- W2507350431 cites W2122698051 @default.
- W2507350431 cites W2123526148 @default.
- W2507350431 cites W2129176513 @default.
- W2507350431 cites W2129719181 @default.
- W2507350431 cites W2130105877 @default.
- W2507350431 cites W2134897395 @default.
- W2507350431 cites W2136354987 @default.
- W2507350431 cites W2137467802 @default.
- W2507350431 cites W2139588758 @default.
- W2507350431 cites W2142599639 @default.
- W2507350431 cites W2149514290 @default.
- W2507350431 cites W2154409731 @default.
- W2507350431 cites W2155366909 @default.
- W2507350431 cites W2157294661 @default.
- W2507350431 cites W2157890931 @default.
- W2507350431 cites W2164778107 @default.
- W2507350431 cites W2167261236 @default.
- W2507350431 cites W2171121967 @default.
- W2507350431 cites W2255135906 @default.
- W2507350431 cites W2300846039 @default.
- W2507350431 cites W2316732799 @default.
- W2507350431 cites W2318854599 @default.
- W2507350431 cites W2332080456 @default.
- W2507350431 cites W2395931110 @default.