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- W2507360947 abstract "To evaluate whether freezing embryos, for a subsequent frozen embryo transfer (FET), would compromise the outcome in frozen donor egg IVF cycles when preimplantation genetic screening (PGS) was performed. A retrospective study of frozen donor egg IVF with PGS cycles done at the same IVF lab where blastocyst stage embryos were either biopsied on day 5 for PGS and transferred fresh on day 6 of culture or blastocyst stage embryos were biopsied for PGS on day 5, 6 or 7 of culture then frozen. The frozen embryos were subsequently transferred in a frozen embryo transfer cycle. Charts were reviewed for patient’s and partner’s age, number of frozen donor eggs thawed, number of eggs surviving the thaw, number of fertilized eggs, number of embryos biopsied on day 5, 6 and 7 of culture, PGS results, whether the transfer was a fresh or frozen embryo, transferred embryos number and grade, implantation, pregnancy and viable pregnancy rates. Chi square and student’s t-tests were performed to compare categorical and continuous variables, respectively. From January 2014 until January 2016, 19 frozen donor egg IVF with PGS cycles were identified. In 6 cycles, embryo biopsy was performed on culture day 5 with 24 hour turnaround PGS and embryo transfer on day 6; 4 cycles (66.7%) resulted in biochemical pregnancy and 3 cycles (50%) continued to clinical pregnancy/delivery. The implantation rate was 50% (6/12). In 13 cycles, embryo biopsy was performed on culture days 5, 6 or 7. The embryos were frozen on the same day of biopsy. FET occurred in a subsequent cycle after PGS results were back; 11 cycles (84.6%) resulted in biochemical pregnancy, 8 cycles (61.5%) continued to clinical pregnancy/delivery and one cycle resulted in an ectopic pregnancy. The implantation rate was 70% (14/20). There was no significant difference in the biochemical pregnancy, clinical pregnancy/delivery and implantation rates between the 2 groups. There was no significant difference in the age of the recipients, fertilization rate, number of biopsied embryos or number and grade of transferred embryos. 6 of the 13 FET cycles had only embryos biopsied on culture day 6 or 7 available for transfer, where a fresh embryo transfer after 24 hour turnaround PGS would not have been feasible. Freezing embryos after blastocyst stage biopsy for PGS in a frozen donor egg IVF cycle does not seem to result in lower success rate when compare to a fresh embryo transfer. Frozen donor egg IVF with PGS and subsequent FET would allow for the biopsy of culture day 6 and 7 blastocysts." @default.
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- W2507360947 date "2016-09-01" @default.
- W2507360947 modified "2023-10-15" @default.
- W2507360947 title "Fresh vs frozen embryo transfer in frozen donor egg IVF and preimplantation genetic screening cycles" @default.
- W2507360947 doi "https://doi.org/10.1016/j.fertnstert.2016.07.405" @default.
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