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- W2507370632 abstract "ABSTRACT A novel and highly accurate diagnostic assay platform was established for rapid identification of FKS mutations associated with echinocandin resistance in Candida glabrata . The assay platform uses allele-specific molecular beacon and DNA melt analysis following asymmetric PCR. A dual assay for FKS1 and FKS2 was developed to identify within 3 h the most common and clinically relevant resistance-associated mutations, including 8 FKS1 HS1 (wild type [WT], S629P, F625S, D632Y, D632E [T1896G], D632E [T1896A], I634V, and F625F) and 7 FKS2 HS1 (WT, F659del, F659S, F659V, F659L, S663P, and S663F) genotypes. A blinded panel of 188 C. glabrata clinical isolates was tested by both assays. The molecular diagnostic results from the dual assay were 100% concordant with data obtained from DNA sequencing. This platform has the potential to overcome the deficiencies of existing in vitro susceptibility-based assays to identify echinocandin-resistant C. glabrata and holds promise as a surrogate diagnostic method to better direct echinocandin therapy." @default.
- W2507370632 created "2016-09-16" @default.
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- W2507370632 date "2016-11-01" @default.
- W2507370632 modified "2023-10-17" @default.
- W2507370632 title "Rapid Detection of <i>FKS</i> -Associated Echinocandin Resistance in Candida glabrata" @default.
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- W2507370632 doi "https://doi.org/10.1128/aac.01574-16" @default.
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