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• W2507375103 endingPage "e4713" @default.
• W2507375103 startingPage "e4713" @default.
• W2507375103 abstract "Autoantibodies directed against the Ku autoantigen are present in systemic sclerosis (SSc) and have been associated with myositis overlap and interstitial lung disease (ILD). However, there is a paucity of data on the clinical correlates of anti-Ku antibodies in the absence of other SSc-specific antibodies. The aim of this study was to assess the clinical correlates of single-specificity anti-Ku in SSc. An international (Canada, Australia, USA, Mexico) cohort of 2140 SSc subjects was formed, demographic and clinical variables were harmonized, and sera were tested for anti-Ku using a line immunoassay. Associations between single-specificity anti-Ku antibodies (i.e., in isolation of other SSc-specific antibodies) and outcomes of interest, including myositis, ILD, and survival, were investigated. Twenty-four (1.1%) subjects had antibodies against Ku, and 13 (0.6%) had single-specificity anti-Ku antibodies. Subjects with single-specificity anti-Ku antibodies were more likely to have ILD (58% vs 34%), and to have increased creatine kinase levels (>3× normal) at baseline (11% vs 1%) and during follow-up (10% vs 2%). No difference in survival was noted in subjects with and without single-specificity anti-Ku antibodies. This is the largest cohort to date focusing on the prevalence and disease characteristics of single-specificity anti-Ku antibodies in subjects with SSc. These results need to be interpreted with caution in light of the small sample. International collaboration is key to understanding the clinical correlates of uncommon serological profiles in SSc." @default.
• W2507375103 created "2016-09-16" @default.
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• W2507375103 date "2016-08-01" @default.
• W2507375103 modified "2023-10-17" @default.
• W2507375103 title "Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects" @default.
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• W2507375103 doi "https://doi.org/10.1097/md.0000000000004713" @default.
• W2507375103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5008592" @default.
• W2507375103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27583908" @default.
• W2507375103 hasPublicationYear "2016" @default.
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