FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2507379588> ?p ?o ?g. }

• W2507379588 endingPage "106" @default.
• W2507379588 startingPage "98" @default.
• W2507379588 abstract "<b><i>Background:</i></b> Nintedanib is approved for the treatment of idiopathic pulmonary fibrosis (IPF) and has been shown to slow disease progression by reducing annual lung function decline. <b><i>Objective:</i></b> To evaluate the results of a large cohort of IPF patients treated with nintedanib within a compassionate use program (CUP) in Germany (9 centers). <b><i>Methods:</i></b> Patients (≥40 years) were required to have a confirmed diagnosis of IPF, a forced vital capacity (FVC) ≥50% predicted (pred.) and a carbon monoxide diffusing capacity (D<smlcap>LCO</smlcap>) 30-79% pred. and not to be eligible for pirfenidone treatment. Clinical data, pulmonary function tests and adverse events were recorded up to July 2015. <b><i>Results:</i></b> Sixty-two patients (48 male/14 female) with moderate IPF (FVC 64 ± 17% pred. and D<smlcap>LCO</smlcap> 40 ± 10% pred.) were treated with nintedanib. 77% of patients switched from pirfenidone (mean treatment duration 14 ± 2 months) mostly due to disease progression (mean decline in FVC 7.4 ± 3% pred. in the 6 months prior to nintedanib intake). Initiation of nintedanib treatment occurred 69 ± 29 months after IPF diagnosis, and mean treatment duration was 8 ± 4 months. Most patients (63%) stabilized 6 months after treatment start (mean FVC decline 3 ± 1 vs. -17 ± 2% in patients with disease progression; p < 0.01). The most common adverse events were diarrhea (63%) and weight loss (50%). Dose reduction occurred in 34% of cases and treatment discontinuation in 10%. <b><i>Conclusion:</i></b> Nintedanib treatment was generally well tolerated and was associated with FVC stabilization in the majority of IPF patients in this CUP setting where most patients were not treatment naïve. Our data are in agreement with the previously published data." @default.
• W2507379588 created "2016-09-16" @default.
• W2507379588 creator A5006969715 @default.
• W2507379588 creator A5012574601 @default.
• W2507379588 creator A5020923092 @default.
• W2507379588 creator A5027241081 @default.
• W2507379588 creator A5029942857 @default.
• W2507379588 creator A5038615410 @default.
• W2507379588 creator A5039583899 @default.
• W2507379588 creator A5081500145 @default.
• W2507379588 creator A5082032036 @default.
• W2507379588 date "2016-01-01" @default.
• W2507379588 modified "2023-10-18" @default.
• W2507379588 title "Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis" @default.
• W2507379588 cites W1512131644 @default.
• W2507379588 cites W1672592297 @default.
• W2507379588 cites W1757222072 @default.
• W2507379588 cites W1972319394 @default.
• W2507379588 cites W2004407498 @default.
• W2507379588 cites W2104766198 @default.
• W2507379588 cites W2111256250 @default.
• W2507379588 cites W2138871107 @default.
• W2507379588 cites W2146127863 @default.
• W2507379588 cites W2152974152 @default.
• W2507379588 cites W2167383172 @default.
• W2507379588 cites W2195044858 @default.
• W2507379588 cites W2555340157 @default.
• W2507379588 cites W2562788813 @default.
• W2507379588 doi "https://doi.org/10.1159/000448288" @default.
• W2507379588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27544537" @default.
• W2507379588 hasPublicationYear "2016" @default.
• W2507379588 type Work @default.
• W2507379588 sameAs 2507379588 @default.
• W2507379588 citedByCount "49" @default.
• W2507379588 countsByYear W25073795882017 @default.
• W2507379588 countsByYear W25073795882018 @default.
• W2507379588 countsByYear W25073795882019 @default.
• W2507379588 countsByYear W25073795882020 @default.
• W2507379588 countsByYear W25073795882021 @default.
• W2507379588 countsByYear W25073795882022 @default.
• W2507379588 countsByYear W25073795882023 @default.
• W2507379588 crossrefType "journal-article" @default.
• W2507379588 hasAuthorship W2507379588A5006969715 @default.
• W2507379588 hasAuthorship W2507379588A5012574601 @default.
• W2507379588 hasAuthorship W2507379588A5020923092 @default.
• W2507379588 hasAuthorship W2507379588A5027241081 @default.
• W2507379588 hasAuthorship W2507379588A5029942857 @default.
• W2507379588 hasAuthorship W2507379588A5038615410 @default.
• W2507379588 hasAuthorship W2507379588A5039583899 @default.
• W2507379588 hasAuthorship W2507379588A5081500145 @default.
• W2507379588 hasAuthorship W2507379588A5082032036 @default.
• W2507379588 hasBestOaLocation W25073795881 @default.
• W2507379588 hasConcept C126322002 @default.
• W2507379588 hasConcept C165637977 @default.
• W2507379588 hasConcept C2777714996 @default.
• W2507379588 hasConcept C2778341716 @default.
• W2507379588 hasConcept C2779832356 @default.
• W2507379588 hasConcept C2780171596 @default.
• W2507379588 hasConcept C3018587741 @default.
• W2507379588 hasConcept C55520419 @default.
• W2507379588 hasConcept C71924100 @default.
• W2507379588 hasConcept C75603125 @default.
• W2507379588 hasConcept C90924648 @default.
• W2507379588 hasConceptScore W2507379588C126322002 @default.
• W2507379588 hasConceptScore W2507379588C165637977 @default.
• W2507379588 hasConceptScore W2507379588C2777714996 @default.
• W2507379588 hasConceptScore W2507379588C2778341716 @default.
• W2507379588 hasConceptScore W2507379588C2779832356 @default.
• W2507379588 hasConceptScore W2507379588C2780171596 @default.
• W2507379588 hasConceptScore W2507379588C3018587741 @default.
• W2507379588 hasConceptScore W2507379588C55520419 @default.
• W2507379588 hasConceptScore W2507379588C71924100 @default.
• W2507379588 hasConceptScore W2507379588C75603125 @default.
• W2507379588 hasConceptScore W2507379588C90924648 @default.
• W2507379588 hasIssue "2" @default.
• W2507379588 hasLocation W25073795881 @default.
• W2507379588 hasLocation W25073795882 @default.
• W2507379588 hasLocation W25073795883 @default.
• W2507379588 hasLocation W25073795884 @default.
• W2507379588 hasOpenAccess W2507379588 @default.
• W2507379588 hasPrimaryLocation W25073795881 @default.
• W2507379588 hasRelatedWork W2555155415 @default.
• W2507379588 hasRelatedWork W2556745572 @default.
• W2507379588 hasRelatedWork W2906041115 @default.
• W2507379588 hasRelatedWork W2986781304 @default.
• W2507379588 hasRelatedWork W2991333012 @default.
• W2507379588 hasRelatedWork W3087338830 @default.
• W2507379588 hasRelatedWork W3087598739 @default.
• W2507379588 hasRelatedWork W3092759236 @default.
• W2507379588 hasRelatedWork W3093425191 @default.
• W2507379588 hasRelatedWork W3212518578 @default.
• W2507379588 hasVolume "92" @default.
• W2507379588 isParatext "false" @default.
• W2507379588 isRetracted "false" @default.
• W2507379588 magId "2507379588" @default.
• W2507379588 workType "article" @default.